Home > Name List By 8 > 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2, 4-b]pyridine

CAS No 100643-71-8 , 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,
4-b]pyridine

  • Name: 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,
    4-b]pyridine
  • Synonyms: Aerius;Clarinex; 100643-71-8; Neoclarityn; Descarboethoxyloratadine;8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,
    4-b]pyridine; Clarinex RediTabs; Desloratidine; Claramax;
  • CAS Registry Number:
  • Melting Point: 150-151ºC
  • Flash Point: 236.8 ºC
  • Boiling Point: 467.9 ºC at 760 mmHg
  • Density: 1.221 g/cm3
  • Refractive index: 1.625
  • Water Solubility: Freely soluble in methanol.
  • Flash Point: 236.8 ºC
  • Molecular Weight: 310.82056
  • InchiKey: JAUOIFJMECXRGI-UHFFFAOYSA-N
  • InChI: InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)
    13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
  • Molecular Formula: C19H19ClN2
  • Molecular Structure:CAS No:100643-71-8 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,<br />4-b]pyridine

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References of 8-chloro-11-piperidin-4-ylidene-5,6-dihydrobenzo[1,2]cyclohepta[2,
4-b]pyridine
Title: Desloratadine
CAS Registry Number: 100643-71-8
CAS Name: 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Synonyms: descarboethoxyloratadine
Manufacturers' Codes: Sch-34117
Trademarks: Clarinex (Schering-Plough)
Molecular Formula: C19H19ClN2
Molecular Weight: 310.82
Percent Composition: C 73.42%, H 6.16%, Cl 11.41%, N 9.01%
Literature References: Nonsedating-type histamine H1-receptor antagonist; active metabolite of loratadine, q.v. Also inhibits generation and release of inflammatory mediators from basophils and mast cells. Prepn: D. P. Schumacher et al., EP 208855; F. J. Villani, J. K. Wong, US 4659716 (both 1987 to Schering). GLC determn in plasma: R. Johnson et al., J. Chromatogr. B 657, 125 (1994). Pharmacology: W. Kreutner et al., Arzneim.-Forsch. 50, 345 (2000). Series of articles on clinical efficacy in rhinitis, asthma and urticaria: Allergy 56, Suppl. 65, 1-32 (2001). Review of pharmacology, pharmacokinetics and clinical efficacy: R. S. Geha, E. O. Meltzer, J. Allergy Clin. Immunol. 107, 751-762 (2001); D. K. Agrawal, Expert Opin. Invest. Drugs 10, 547-560 (2001).
Properties: Crystals from hexane, mp 150-151°. Slightly sol in water; very sol in ethanol, propylene glycol.
Melting point: mp 150-151°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic; Tricyclics; Other Tricyclics.