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CAS No 10102-43-9 , nitric oxide

  • Name: nitric oxide
  • Synonyms: Amidogen; nitrosyl; Nitric oxide trimer;nitric oxide;Mononitrogen monoxide; Nitrosyl radical; nitrogen monooxide; INOmax; oxoazanyl; oxo-;
  • CAS Registry Number:
  • Transport: UN 1660 2
  • Melting Point: −163.6 °C(lit.)
  • Flash Point: °C
  • Boiling Point: −151.7 °C(lit.)
  • Density: 1.24 g/cmsup>3
  • Safety Statements: A poison gas. A severe eye, skin, and mucous membrane irritant. A systemic irritant by inhalation. Mutation data reported. Exposure may occur whenever nitric acid acts upon organic material, such as wood, sawdust, and refuse; it occurs when nitric acid is heated, and when organic nitro compounds are burned, for example, celluloid, cellulose nitrate (guncotton), and dynamite. The action of nitric acid upon metals, as in metal etching and pickling, also liberates the fumes. In high-temperature welding, as with the oxyacetylene or electric torch, the nitrogen and oxygen of the air unite to form oxides of nitrogen. Automobile exhaust and power plant emissions are also sources of NOx. Exposure occurs in many manufacturing processes when nitric acid is made or used. Oxides of nitrogen have been implicated as a cause of acid rain.The oxides of nitrogen are somewhat soluble in water, reacting with it to form nitric and nitrous acids. This is the action that takes place deep in the respiratory system. The acids formed are irritating and can cause congestion in the throat and bronchi and edema of the lungs. The acids are neutralized by the alkalies present in the tissues, with the formation of nitrates and nitrites. The latter may cause some arterial dilation, fall in blood pressure, headache, and dizziness, and there may be some formation of methemoglobin. However, the nitrite effect is of secondary importance.Because of their relatively low solubility in water, the nitrogen oxides are initially only slightly irritating to the mucous membranes of the upper respiratory tract. Their warning power is therefore low, and dangerous amounts of the fumes may be breathed before the worker notices any real discomfort. Higher concentrations (60–150 ppm) cause immediate irritation of the nose and throat, with coughing and burning in the throat and chest. These symptoms often clear upon breathing fresh air, and the worker may feel well for several hours. Some 6–24 hours after exposure, a sensation of tightness and burning in the chest develops, followed by shortness of breath, sleeplessness, and restlessness. Dyspnea and air hunger may increase rapidly with development of cyanosis and loss of consciousness followed by death. In cases that recover from the pulmonary edema, there is usually no permanent disability, but pneumonia may develop later. Concentrations of 100–150 ppm are dangerous for short exposures of 30–60 minutes. Concentrations of 200–700 ppm may be fatal after even very short exposures.Continued exposure to low concentrations of the fumes, insufficient to cause pulmonary edema, is said to result in chronic irritation of the respiratory tract, with cough, headache, loss of appetite, dyspepsia, corrosion of the teeth, and gradual loss of strength.Exposure to NOx is always potentially serious, and persons so exposed should be kept under close observation for at least 48 hours.An oxidizer. The liquid is a sensitive explosive. Explosive reaction with carbon disulfide (when ignited), methanol (when ignited), pentacarbonyl iron (at 50°C), phosphine + oxygen, sodium diphenylketyl, dichlorine oxide, fluorine, nitrogen trichloride, ozone, perchloryl fluoride (at 100–300°C), vinyl chloride. Reacts to form explosive products with dienes (e.g., 1,3-butadiene, cyclopentadiene, propadiene).Can react violently with acetic anhydride, Al, amorphous boron, BaO, BCl3, CsHC2, calcium, carbon + potassium hydrogen tartrate, charcoal, ClO, pyrophoric chromium, 1,2-dichloroethane, dichloroethylene, ethylene, fuels, hydrocarbons, hydrogen + oxygen, Na2O, uns-dimethyl hydrazine, NH3, CHCl3, Fe, Mg, Mn, CH2Cl2, olefins, phosphorus, PNH2, PH3, potassium, potassium sulfide, propylene, rubidium acetylide, Na, S, tungsten carbide, trichloroethylene, 1,1,1-trichloroethane, uns-tetrachloroethane, uranium, uranium dicarbide. Will react with water or steam to produce heat and corrosive fumes; can react vigorously with reducing materials.Analytical Methods:   For occupational chemical analysis use OSHA: #ID-109.
  • Hazard Symbols: Supports combustion. Toxic by inhalation, strong irritant to skin and mucous membranes. TLV: 25 ppm.
  • Flash Point: °C
  • EINECS: 233-271-0
  • Molecular Weight: 30.0061
  • InChI: InChI=1S/NO/c1-2
  • Risk Statements: 8-23-34-44
  • Molecular Formula: NO
  • Molecular Structure:CAS No:10102-43-9 nitric oxide
References of nitric oxide
Title: Nitric Oxide
CAS Registry Number: 10102-43-9
CAS Name: Nitrogen oxide (NO)
Synonyms: mononitrogen monoxide; nitrogen monoxide; endothium-derived relaxing factor; EDRF
Molecular Formula: NO
Molecular Weight: 30.01
Percent Composition: N 46.67%, O 53.31%
Literature References: Highly reactive, potentially toxic gas produced by the partial oxidation of atmospheric nitrogen. Major air pollutant along with its oxidative by-products (NOx) resulting from incomplete combustion of fossil fuels. Also found ubiquitously in animals; generated in vivo from arginine, q.v., by nitric oxide synthase (NOS). Increases guanylate cyclase activity to produce cyclic GMP, q.v. Involved in a wide range of physiological functions, including vasodilation, neurotransmission, cytotoxicity of macrophages, and inhibition of platelet aggregation. Laboratory prepn: Blanchard, Inorg. Synth. 2, 126 (1946); Schenk in Handbook of Preparative Inorganic Chemistry vol. 1, G. Brauer, Ed. (Academic Press, New York, 2nd ed., 1963) pp 485-487. General reviews: Beattie, "Nitric Oxide" in Mellor's Vol. VIII, supplement II, Nitrogen (part 2) 216-240 (1967); Jones in Comprehensive Inorganic Chemistry vol. 2, J. C. Bailar, Jr. et al., Eds. (Pergamon Press, Oxford, 1973) pp 323-334. Role in cGMP production: W. P. Arnold et al., Proc. Natl. Acad. Sci. USA 74, 3203 (1977). Identification of endothelium dependent vasorelaxation: R. F. Furchgott, J. V. Zawadzki, Nature 288, 373 (1980). Identity of NO and EDRF: L. J. Ignarro et al., Proc. Natl. Acad. Sci. USA 84, 9265 (1987). Reviews of physiological role: S. Moncada et al., Pharmacol. Rev. 43, 109-142 (1991); A. R. Butler, D. L. H. Williams, Chem. Soc. Rev. 22, 233-242 (1993). Role in airway function: R. J. Martin et al., Semin. Perinatol. 26, 432 (2002). Clinical trial of inhaled NO in neonatal respiratory failure: G. M. Sokol, R. A. Ehrenkranz, ibid. 27, 311 (2003). Review of pharmacology and therapeutic potential of inhaled NO: F. Ichinose et al., Circulation 109, 3106-3111 (2004). Review of chemistry: D. L. H. Williams, Org. Biomol. Chem. 1, 441-449 (2003); of coordination chemistry in bio-inorganic systems: J. A. McCleverty, Chem. Rev. 104, 403-418 (2004).
Properties: Colorless gas. Burns only when heated with hydrogen. triple pt -163.6°. bp -151.8°. d-150.2 (liq) 1.27. Relative d (gas) 1.036 (air = 1). Absolute d (gas) 1.227 (air = 1). nD25 1.0002697. Trouton constant 27.1. Contains an odd number of electrons and is paramagnetic. Crit temp -92.9°. Crit press. 64.6 atm. Heat of formation (18°): -21.5 kcal/mole. Heat of vaporization (bp): 3.293 kcal/mole. Ionization potential: 9.26 eV. Electron affinity: 0.024 eV. Solubility in water (ml/100 ml; 1 atm): 7.38 (0°); 4.6 (20°); 2.37 (60°). Combines with oxygen to form NO2 and with chlorine and bromine to form the nitrosyl halides, such as NOCl, see N. V. Sidgwick, Chemical Elements and Their Compounds vol. I (Oxford, 1950) p 683.
Boiling point: bp -151.8°
Index of refraction: nD25 1.0002697
Density: d-150.2 (liq) 1.27; Relative d (gas) 1.036 (air = 1); Absolute d (gas) 1.227 (air = 1)
CAUTION: Potential symptoms of overexposure are irritation of eyes, wet skin, nose and throat; drowsiness; unconsciousness; methemoglobinemia. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 224. On contact with air, nitric oxide is converted to the highly poisonous nitrogen dioxide, q.v. Respiratory protection and adequate ventilation should be used to avoid overexposure. See Patty's Industrial Hygiene and Toxicology vol. 2F, G. D Clayton, F. E. Clayton, Eds. (John Wiley & Sons, New York, 4th ed., 1994) pp 4566-4591.
Use: Manuf of nitric acid; in the bleaching of rayon; as stabilizer (to prevent free-radical decompn) for propylene, methyl ether, etc.
Therap-Cat: Vasodilator (pulmonary); in treatment of neonatal cardiorespiratory failure.