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CAS No 101530-10-3 , (2E)-2-[4-(2-chlorophenyl)-1,
3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile Search by region : Germany

  • Name: (2E)-2-[4-(2-chlorophenyl)-1,
    3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile
  • Synonyms: BRN 4819111; TJN-318; Latoconazole;(2E)-2-[4-(2-chlorophenyl)-1,
    3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile; 101530-10-3; NND-318; Astat;lanoconazole;
  • CAS Registry Number:
  • Melting Point: 141.50C
  • Density: 1.43 g/cm3
  • Refractive index: 1.725
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 203-865-4
  • Molecular Weight: 319.8323
  • InchiKey: ZRTQSJFIDWNVJW-WYMLVPIESA-N
  • InChI: InChI=1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-
    6-5-17-9-18/h1-6,9,13H,8H2/b14-12+
  • Risk Statements: 22
  • Molecular Formula: C14H10ClN3S2
  • Molecular Structure:CAS No:101530-10-3 (2E)-2-[4-(2-chlorophenyl)-1,<br />3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile

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101530-10-3 Lanoconazole

  • Lanoconazole
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
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References of (2E)-2-[4-(2-chlorophenyl)-1,
3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile
Title: Lanoconazole
CAS Registry Number: 101530-10-3
CAS Name: (E)-(±)-a-[4-(2-Chlorophenyl)-1,3-dithiolan-2-ylidene]-1H-imidazole-1-acetonitrile
Synonyms: latoconazole
Manufacturers' Codes: TJN-318; NND-318
Trademarks: Astat (Nihon Nohyaku)
Molecular Formula: C14H10ClN3S2
Molecular Weight: 319.83
Percent Composition: C 52.57%, H 3.15%, Cl 11.08%, N 13.14%, S 20.05%
Literature References: Prepn: A. Soe et al., JP Kokai 85 218387; idem et al., US 4636519 (1985, 1987 both to Nihon Nohyaku). In vivo antifungal activity: H. Oka et al., Arzneim.-Forsch. 42, 345 (1992); Y. Niwano et al., Antimicrob. Agents Chemother. 38, 2204 (1994). Toxicity study: P. L. Munt et al., Oyo Yakuri 43, 195 (1992).
Properties: Light yellow crystals, mp 141.5°. LD50 in male, female mice, rats (mg/kg): 3224, 2715, 993, 652 orally; 2158, 1743, 1655, 2596 i.p.; >5000 both species s.c. LD50 dermally in rats: >5000 mg/kg (Munt).
Melting point: mp 141.5°
Toxicity data: LD50 in male, female mice, rats (mg/kg): 3224, 2715, 993, 652 orally; 2158, 1743, 1655, 2596 i.p.; >5000 both species s.c.; LD50 dermally in rats: >5000 mg/kg (Munt)
Therap-Cat: Antifungal.
Keywords: Antifungal (Synthetic); Imidazoles.