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CAS No 103060-53-3 , Daptomycin

  • Name: Daptomycin
  • Synonyms: 4)-lactone, (aS)-; LY 146032;1-Oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane,cyclic peptide deriv.; Daptomicina;4)-lactone; Cidecin;Daptomycin;Daptomycinum; Deptomycin; N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithyl-L-a-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R)-3-methyl-L-a-glutamyl-(aS)-a,2-diamino-g-oxobenzenebutanoicacid (13® Daptomycine; Dapcin; Benzenebutanoic acid, N-(1-oxodecyl)-L-tryptophyl-D-asparaginyl-L-a-aspartyl-L-threonylglycyl-L-ornithyl-L-a-aspartyl-D-alanyl-L-a-aspartylglycyl-D-seryl-(3R)-3-methyl-L-a-glutamyl-a,2-diamino-g-oxo-, (13® Cubicin;
  • CAS Registry Number:
  • Density: 1.45 g/cm3
  • Refractive index: 1.638
  • Molecular Weight: 1620.67
  • InChI: InChI=1/C72H101N17O26/c1-5-6-7-8-9-10-11-22-53(93)81-44(25-38-31-76-42-20-15-13-17-39(38)42)66(108)84-45(27-52(75)92)67(109)86-48(30-59(102)103)68(110)89-61-37(4)115-72(114)49(26-51(91)40-18-12-14-19-41(40)74)87-71(113)60(35(2)24-56(96)97)88-69(111)50(34-90)82-55(95)32-77-63(105)46(28-57(98)99)83-62(104)36(3)79-65(107)47(29-58(100)101)85-64(106)43(21-16-23-73)80-54(94)33-78-70(61)112/h12-15,17-20,31,35-37,43-50,60-61,76,90H,5-11,16,21-30,32-34,73-74H2,1-4H3,(H2,75,92)(H,77,105)(H,78,112)(H,79,107)(H,80,94)(H,81,93)(H,82,95)(H,83,104)(H,84,108)(H,85,106)(H,86,109)(H,87,113)(H,88,111)(H,89,110)(H,96,97)(H,98,99)(H,100,101)(H,102,103)
  • Molecular Formula: C72H101N17O26
  • Molecular Structure:CAS No:103060-53-3 Daptomycin

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References of Daptomycin
Title: Daptomycin
CAS Registry Number: 103060-53-3
Manufacturers' Codes: LY-146032
Trademarks: Cidecin (Cubist); Cubicin (Cubist)
Molecular Formula: C72H101N17O26
Molecular Weight: 1620.67
Percent Composition: C 53.36%, H 6.28%, N 14.69%, O 25.67%
Literature References: Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Prepn: B. J. Abbott et al., US 4537717 (1985 to Eli Lilly); M. Debono et al., J. Antibiot. 41, 1093 (1988). Mechanism of action study: N. E. Allen et al., Antimicrob. Agents Chemother. 31, 1093 (1987); and structure determn: D. Jung et al., Chem. Biol. 11, 949 (2004). Comparative in vitro antibacterial spectrum: I. A. Critchley et al., J. Antimicrob. Chemother. 51, 639 (2003). Clinical pharmacokinetics: J. R. Woodworth et al., Antimicrob. Agents Chemother. 36, 318 (1992). Clinical trial in skin infections: R. D. Arbeit et al., Clin. Infect. Dis. 38, 1673 (2004). Review of pharmacology and clinical evaluations: F. P. Tully et al., Expert Opin. Invest. Drugs 8, 1223-1238 (1999); L. P. Kotra Curr. Opin. Anti-Infect. Invest. Drugs 2, 185-205 (2000).
Properties: uv max (ethanol): 220, 260 nm (e 46500, 10000). LD50 i.v. in mice: 600 mg/kg (Debono).
Absorption maximum: uv max (ethanol): 220, 260 nm (e 46500, 10000)
Toxicity data: LD50 i.v. in mice: 600 mg/kg (Debono)
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides.