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CAS No 103577-45-3 , 2-[[3-methyl-4-(2,2,
2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole

  • Name: 2-[[3-methyl-4-(2,2,
    2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
  • Synonyms: Lanzor; Limpidex; Monolitum;2-[[3-methyl-4-(2,2,
    2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole; Agopton; Opiren; Lanzopral; Prevacid;Bamalite; Ogastro;
  • CAS Registry Number:
  • Flash Point: 289.9 ºC
  • Boiling Point: 555.8ºC at 760 mmHg
  • Density: 1.5 g/cm3
  • Refractive index: 1.591
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 289.9 ºC
  • Molecular Weight: 369.36147
  • InchiKey: MJIHNNLFOKEZEW-UHFFFAOYSA-N
  • InChI: InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,
    18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)
  • Risk Statements: S26;S36
  • Molecular Formula: C16H14F3N3O2S
  • Molecular Structure:CAS No:103577-45-3 2-[[3-methyl-4-(2,2,<br />2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole

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References of 2-[[3-methyl-4-(2,2,
2-trifluoroethoxy)pyridin-2-yl]methylsulfinyl]-1H-benzimidazole
Title: Lansoprazole
CAS Registry Number: 103577-45-3
CAS Name: 2-[[[3-Methyl-4-(2,2,2-trifluoro-ethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
Synonyms: 2-(2-benzimidazolylsulfinylmethyl)-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine
Manufacturers' Codes: A-65006; AG-1749
Trademarks: Agopton (Takeda); Lansox (Takeda); Lanzor (Aventis); Limpidex (Sigma-Tau); Ogast (Takeda); Prevacid (TAP); Takepron (Takeda); Zoton (Wyeth)
Molecular Formula: C16H14F3N3O2S
Molecular Weight: 369.36
Percent Composition: C 52.03%, H 3.82%, F 15.43%, N 11.38%, O 8.66%, S 8.68%
Literature References: Gastric proton-pump inhibitor. Prepn: A. Nohara, Y. Maki, EP 174726; eidem, US 4628098 (both 1986 to Takeda). HPLC determn in plasma: T. Uno et al., J. Chromatogr. B 816, 309 (2005). Pharmacology: H. Satoh et al., J. Pharmacol. Exp. Ther. 248, 806 (1989). Mechanism of action study: H. Nagaya et al., ibid. 252, 1289 (1990). Clinical pharmacology and effect on human gastric acid secretion: P. Müller et al., Aliment. Pharmacol. Ther. 3, 193 (1989). Review of pharmacology and clinical experience: H. D. Langtry, M. I. Wilde, Drugs 54, 473-500 (1997). Comparative clinical trial with esomeprazole in erosive esophagitis: C. W. Howden et al., Clin. Drug Invest. 22, 99 (2002).
Properties: mp 178-182° (dec).
Melting point: mp 178-182° (dec)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Gastric Proton Pump Inhibitor.