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CAS No 103745-39-7 , Fasudil Search by region : China

  • Name: Fasudil
  • Synonyms: 1-(5-Isoquinolinesulfonyl)homopiperazine;Fasudil; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine;
  • CAS Registry Number:
  • Flash Point: 259.9°C
  • Boiling Point: 506.2°Cat760mmHg
  • Density: 1.289g/cm3
  • Safety Statements:
    WGK Germany 3
    RTECS HM4031166
  • Flash Point: 259.9°C
  • Molecular Weight: 291.37
  • InChI: InChI=1/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
  • Molecular Formula: C14H17N3O2S
  • Molecular Structure:CAS No:103745-39-7 Fasudil

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103745-39-7 Fasudil hydrochloride

  • Fasudil hydrochloride, 99.0%Min
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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103745-39-7 Fasudil Hydrochloride

  • China Beijing Mediking Biopharm Co., Ltd [Manufacturer]
  • Tel: +86-10-81769620/ +86-10-81769521
  • Fax: +86-10-81769652
  • Address: Hongxianghong Incubator, Beiqijia Town,
    Changping District
    Beijing China null,nullChina
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103745-39-7 Fasudil

  • Fasudil, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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103745-39-7 Fasudil

  • China Boronsyn Co.,Ltd [Manufacturer]
  • Tel: +86-21-58407925
  • Fax: +86-21-58408291
  • Address: 1213 JunMin Road,Pudong,China null,nullChina
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103745-39-7 Fasudil

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103745-39-7 Fasudil

  • Fasudil, 99%
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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103745-39-7 Fasudil

  • China Maple Chemical Co.,ltd. [Manufacturer]
  • Tel: 86-574- 87512300
  • Fax: 86-574-82095182
  • Address: No.347,Sanbei Road,Sanbei Town,Cixi ,Zhejiang,China Ningbo,ZhejiangChina
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103745-39-7 Fasudil

  • China shanghai sphchem co.,ltd [Manufacturers]
  • Tel: +86-21-56491756 13512199871
  • Fax: 0
  • Address: NO.133, Wuye, Yangxin Road ,Shanghai China shanghai,shanghai ChinaChina
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103745-39-7 Fasudil

  • China Xilin Chemical Group Co., Ltd null
  • Tel: +86-(0)-15527136576
  • Fax: +86-(27)-83820093
  • Address: 16# Luojiashan, Wuchang District, Wuhan, Hubei 430071, null,nullChina
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103745-39-7 Fasudil

  • China Hangzhou APIChem Technology Co., Ltd. [Manufacturers]
  • Tel: +86-571-56059907
  • Fax: +86-571-56059907
  • Address: Hangzhou E&T Development Zone, Hangzhou, Zhejiang, 310018, China Hangzhou,ZhejiangChina
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References of Fasudil
Title: Fasudil
CAS Registry Number: 103745-39-7
CAS Name: Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine
Synonyms: N-(5-isoquinolinesulfonyl)-1,4-perhydrodiazepine; 1-(5-isoquinolinesulfonyl)homopiperazine
Molecular Formula: C14H17N3O2S
Molecular Weight: 291.37
Percent Composition: C 57.71%, H 5.88%, N 14.42%, O 10.98%, S 11.00%
Literature References: Intracellular calcium antagonist. Prepn: H. Hidaka, T. Sone, EP 187371; eidem, US 4678783 (1986, 1987 both to Asahi); A. Morikawa et al., Chem. Pharm. Bull. 40, 770 (1992). Pharmacology: T. Asano et al., Br. J. Pharmacol. 98, 1091 (1989). Mechanism of action: idem et al., J. Pharmacol. Exp. Ther. 241, 1033 (1987). Clinical trials: M. Shibuya et al., J. Neurosurg. 76, 571 (1992). Acute toxicity: H. Koga et al., Yakuri to Chiryo 20, S1433 (1992), C.A. 117, 226005b (1992). Review of pharmacology and clinical evaluation: M. Shirotani et al., Cardiovasc. Drug Rev. 10, 333-357 (1992).
 
Derivative Type: Hydrochloride
CAS Registry Number: 105628-07-7
Manufacturers' Codes: AT-877; HA-1077
Trademarks: Eril (Asahi)
Molecular Formula: C14H17N3O2S.HCl
Molecular Weight: 327.83
Percent Composition: C 51.29%, H 5.53%, N 12.82%, O 9.76%, S 9.78%, Cl 10.81%
Properties: Crystals from water, mp 220.5°. Also reported as white crystalline powder, mp 219.3° (Shirotani). Sol in water up to 2 ′ 10-2M at pH 5.0-7.0. LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga).
Melting point: mp 220.5°; mp 219.3° (Shirotani)
Toxicity data: LD50 in mice, rats (mg/kg): 67.5, 59.9 i.v.; 124.5, 123.2 s.c.; 273.9, 335.0 orally (Koga)
 
Therap-Cat: Vasodilator (cerebral).
Keywords: Vasodilator (Cerebral).