CAS No 103878-84-8 , N-(2-aminoethyl)-5-chloropyridine-2-carboxamide Search by region : China

Name: N-(2-aminoethyl)-5-chloropyridine-2-carboxamide
Synonyms: n-(2-aminoethyl)-5-chloro-2-pyridinecarboxamide;N-(2-aminoethyl)-5-chloropyridine-2-carboxamide;Ro-19-6327; N-(2-aminoethyl)-5-chloropyridine-2-carboxamide; 103878-84-8; CCRIS 7301;
CAS Registry Number:103878-84-8
Melting Point: 199.637
Flash Point: 194.2°C
Boiling Point: 397.4°Cat760mmHg
Density: 1.286g/cm³
Refractive index: 1.571
Flash Point: 194.2°C
Molecular Weight: 199.6375
InchiKey: JZXRLKWWVNUZRB-UHFFFAOYSA-N
InChI: InChI=1S/C8H10ClN3O/c9-6-1-2-7(12-5-6)8(13)11-4-3-10/h1-2,5H,3-4,10H2,
(H,11,13)
Molecular Formula: C₈H₁₀ClN₃O
Molecular Structure:

Related products

Select to

          
           103878-84-8 Lazabemide
           Lazabemide, Min 99%
 
             Finechemie Co., Ltd. 
             
              [Manufacturer]
Tel: +86-23-99186710 
Fax: +86-23-99186729 
Address: 28th Floor Mordern Building,New-Tech Zone400020  ChongqingCHINA Chongqing,nullChina

           103878-84-8 Lazabemide
           Lazabemide, 99%
 
             Facus Pharmaceutical Co., Ltd. 
             
              [Manufacturer]
Tel: +86-(0)574-62378411   
Fax: +86-(0)574-62378410  
Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 
 
315800  NingboCHINA Ningbo,nullChina

           103878-84-8 LAZABEMIDE
           
             Nanjing Chemlin Chemical Industry Co.,Ltd.
             
              [Manufacturer]
Tel:  +86 25 8369-7070/ +86 138 51816776 (Mobile)
Fax:  +86 25 8345-3275
Address: Rm.902 Longyin Plaza,
No. 217 Zhongshan Rd.
(N)Nanjing 210009,China null,nullChina

Select to

1/1

References of N-(2-aminoethyl)-5-chloropyridine-2-carboxamide

Title: Lazabemide
CAS Registry Number: 103878-84-8
CAS Name: N-(2-Aminoethyl)-5-chloro-2-pyridinecarboxamide
Synonyms: N-(2-aminoethyl)-5-chloropicolinamide
Molecular Formula: C8H10ClN3O
Molecular Weight: 199.64
Percent Composition: C 48.13%, H 5.05%, Cl 17.76%, N 21.05%, O 8.01%
Literature References: Member of a novel class of potent, reversible, and extremely selective monoamine oxidase type B (MAO-B) inhibitors. Prepn: R. Imhof, E. Kyburz, GB 2163746; eidem, US 4764522 (1986, 1988 both to Hoffmann-LaRoche). HPLC determn in plasma: R. Wyss, W. Philipp, J. Chromatogr. 507, 187 (1990). Neurochemical profile: W. E. Haefely et al., Adv. Neurol. 53, 505 (1990). Enzyme binding studies: J. Saura et al., J. Neurosci. 12, 1977 (1992). Clinical trial: Parkinson Study Group, Ann. Neurol. 33, 350 (1993).

Derivative Type: Monohydrochloride
CAS Registry Number: 103878-83-7
Manufacturers' Codes: Ro-19-6327
Molecular Formula: C8H10ClN3O.HCl
Molecular Weight: 236.10
Percent Composition: C 40.70%, H 4.70%, Cl 30.03%, N 17.80%, O 6.78%
Properties: Crystals from methanol/ether, mp 193-195°. Partition coefficient (n-octanol/water) ~0.1. pKa 8.9. LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986).
Melting point: mp 193-195°
pKa: pKa 8.9
Log P: Partition coefficient (n-octanol/water) ~0.1
Toxicity data: LD50 orally in mice: 1000-2000 mg/kg (Imhof, Kyburz, 1986)

Therap-Cat: Antiparkinsonian.
Keywords: Antiparkinsonian; Monoamine Oxidase Inhibitor.