Home > Name List By d > diethyl 2, 6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl] phenyl]-1,4-dihydropyridine-3,5-dicarboxylate

CAS No 103890-78-4 , diethyl
2,
6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]
phenyl]-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: diethyl
    2,
    6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]
    phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: Lacipil;diethyl
    2,
    6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]
    phenyl]-1,4-dihydropyridine-3,5-dicarboxylate; Motens; GR-43659X; 103890-78-4; GR 43659 X; Lacidipinum [Latin]; GR 43659X; Lacidipino [Spanish];
  • CAS Registry Number:
  • Density: 1.127 g/cm3
  • Refractive index: 1.54
  • Safety Statements: S36/37
  • Molecular Weight: 455.54332
  • InchiKey: GKQPCPXONLDCMU-CCEZHUSRSA-N
  • InChI: InChI=1S/C26H33NO6/c1-8-31-24(29)21-16(3)27-17(4)22(25(30)32-9-2)23(21)
    19-13-11-10-12-18(19)14-15-20(28)33-26(5,6)7/h10-15,23,27H,8-9H2,
    1-7H3/b15-14+
  • Risk Statements: R20/21/22
  • Molecular Formula: C26H33NO6
  • Molecular Structure:CAS No:103890-78-4 diethyl<br />2,<br />6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]<br />phenyl]-1,4-dihydropyridine-3,5-dicarboxylate

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References of diethyl
2,
6-dimethyl-4-[2-[(E)-3-[(2-methylpropan-2-yl)oxy]-3-oxoprop-1-enyl]
phenyl]-1,4-dihydropyridine-3,5-dicarboxylate
Title: Lacidipine
CAS Registry Number: 103890-78-4
CAS Name: (E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester
Synonyms: diethyl (E)-4-[2-[2-(tert-butoxycarbonyl)vinyl]phenyl]-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; 4-[o-[(E)-2-carboxyvinyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid 4-tert-butyl diethyl ester
Manufacturers' Codes: GR-43659X; GX-1048
Trademarks: Caldine (Boehringer, Ing.); Lacimen (Menarini); Lacipil (GSK); Lacirex (Guidotti); Midotens (Boehringer, Ing.); Motens (Boehringer, Ing.)
Molecular Formula: C26H33NO6
Molecular Weight: 455.54
Percent Composition: C 68.55%, H 7.30%, N 3.07%, O 21.07%
Literature References: Dihydropyridine calcium channel blocker. Prepn: C. Semeraro et al., DE 3529997; eidem, US 4801599 (1986, 1989 both to Glaxo). Clinical pharmacology: M. Safar et al., Clin. Pharmacol. Ther. 46, 94 (1989). HPTLC determn in urine: V. R. Kharat et al., J. Pharm. Biomed. Anal. 28, 789 (2002). Clinical trial in atherosclerosis: A. Zanchetti et al., Circulation 106, 2422 (2002). Review of use in hypertension: P. L. McCormack, A. J. Wagstaff, Drugs 63, 2327-2356 (2003).
Properties: Crystalline solid from ethyl acetate, mp 174-175°.
Melting point: mp 174-175°
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives.