Home > Name List By 3 > 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1- one

CAS No 10402-90-1 , 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-
one

  • Name: 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-
    one
  • Synonyms: 10402-90-1;3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-
    one;Eprazinonum [INN-Latin]; Eprazinona [INN-Spanish]; EINECS 233-873-3;
  • CAS Registry Number:
  • Density: 1.064 g/cm3
  • Refractive index: 1.579
  • Safety Statements: Poison by intraperitoneal and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
  • EINECS: 233-873-3
  • Molecular Weight: 380.52308
  • InchiKey: BSHWLCACYCVCJE-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H32N2O2/c1-3-28-23(21-10-6-4-7-11-21)19-26-16-14-25(15-17-
    26)18-20(2)24(27)22-12-8-5-9-13-22/h4-13,20,23H,3,14-19H2,1-2H3
  • Molecular Formula: C24H32N2O2
  • Molecular Structure:CAS No:10402-90-1 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-<br />one

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References of 3-[4-(2-ethoxy-2-phenylethyl)piperazin-1-yl]-2-methyl-1-phenylpropan-1-
one
Title: Eprazinone
CAS Registry Number: 10402-90-1
CAS Name: 3-[4-(2-Ethoxy-2-phenylethyl)-1-piperazinyl]-2-methyl-1-phenyl-1-propanone
Synonyms: 3-[4-(b-ethoxyphenethyl)-1-piperazinyl]-2-methylpropiophenone
Molecular Formula: C24H32N2O2
Molecular Weight: 380.52
Percent Composition: C 75.75%, H 8.48%, N 7.36%, O 8.41%
Literature References: Prepn of the dihydrochloride: R. Y. Mauvernay, NL 6602581; idem, US 3448192 (1966, 1969 both to Riom). Pharmacodynamics: J. Vacher et al., Arch. Int. Pharmacodyn. Ther. 165, 1 (1967). Pharmacological study: Y. Kase et al., Nippon Yakurigaku Zasshi 73, 605 (1977), C.A. 88, 15657 (1978). Efficacy: W. Spitzer, Fortschr. Med. 98, 871 (1980). Metabolism: P. Toffel-Nadolny, W. Gielsdorf, Arzneim.-Forsch. 31, 719 (1981).
 
Derivative Type: Dihydrochloride
CAS Registry Number: 10402-53-6
Manufacturers' Codes: 746-CE
Trademarks: Eftapan (Merckle); Mucitux (Riom)
Molecular Formula: C24H32N2O2.2HCl
Molecular Weight: 453.44
Percent Composition: C 63.57%, H 7.56%, N 6.18%, O 7.06%, Cl 15.64%
Properties: White, bitter-tasting crystalline powder, mp 201° (Toffel-Nadolny, Gielsdorf); also reported as crystals from methanol, mp 160° (Mauvernay). LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher).
Melting point: mp 201° (Toffel-Nadolny, Gielsdorf); mp 160° (Mauvernay)
Toxicity data: LD50 in mice (mg/kg): 729 orally, 38 i.v. (Vacher)
 
Therap-Cat: Antitussive.
Keywords: Antitussive.