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CAS No 104206-65-7 , 1,3-Cyclohexanedione,2-[2-nitro-4-(trifluoromethyl)benzoyl]- Search by region : Germany

  • Name: 1,3-Cyclohexanedione,2-[2-nitro-4-(trifluoromethyl)benzoyl]-
  • Synonyms: Nitisinone; SC 0735; Nitisone;1,3-Cyclohexanedione,2-[2-nitro-4-(trifluoromethyl)benzoyl]-; Orfadin;NTBC;2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione;
  • CAS Registry Number:
  • Flash Point: 247.9°C
  • Boiling Point: 486.2°Cat760mmHg
  • Density: 1.484g/cm3
  • Refractive index: 1.535
  • Flash Point: 247.9°C
  • Molecular Weight: 0
  • InChI: InChI=1/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
  • Molecular Formula: C14H10F3NO5
  • Molecular Structure:CAS No:104206-65-7 1,3-Cyclohexanedione,2-[2-nitro-4-(trifluoromethyl)benzoyl]-

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104206-65-7 NITISINONE

  • Germany BIOTREND Chemikalien GmbH [Manufacturer]
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  • Address: BIOTREND Chemikalien GmbH
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References of 1,3-Cyclohexanedione,2-[2-nitro-4-(trifluoromethyl)benzoyl]-
Title: Nitisinone
CAS Registry Number: 104206-65-7
CAS Name: 2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione
Synonyms: NTBC
Trademarks: Orfadin (Swedish Orphan )
Molecular Formula: C14H10F3NO5
Molecular Weight: 329.23
Percent Composition: C 51.07%, H 3.06%, F 17.31%, N 4.25%, O 24.30%
Literature References: Herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. Prepn: C. G. Carter, EP 186118 (1986 to Stauffer); idem, US 5006158 (1991 to ICI). Inhibition of HPPD in plants: M. P. Prisbylla et al., Brighton Crop Prot. Conf. - Weeds 1993, 731; in rats: M. K. Ellis et al., Toxicol. Appl. Pharmacol. 133, 12 (1995). LC determn in plasma: M. Bielenstein et al., J. Chromatogr. B 730, 177 (1999). Clinical evaluation in hereditary tyrosinemia type I: S. Lindstedt et al., Lancet 340, 813 (1992). Review of toxicology and therapeutic development: E. A. Lock et al, J. Inherited Metab. Dis. 21, 498-506 (1998); of clinical experience: E. Holme, S. Lindstedt, ibid. 507-517.
Properties: Solid, mp 88-94°.
Melting point: mp 88-94°
Therap-Cat: In treatment of inherited tyrosinemia type I.