Home > Name List By 1 > 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)- Switzerland

CAS No 105219-56-5 , 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)- Search by region : Switzerland

  • Name: 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-
  • Synonyms: 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-; WEB-2086; Apafanto;Apafant; WEB 2086BS; Apafantum [INN-Latin]; Apafantum; Apafanto [INN-Spanish]; Web 2086; triazolodiazepine;
  • CAS Registry Number:
  • Flash Point: 389.4°C
  • Boiling Point: 720.2°Cat760mmHg
  • Density: 1.48
  • Refractive index: 1.733
  • Flash Point: 389.4°C
  • Molecular Weight: 455.96038
  • InchiKey: JGPJQFOROWSRRS-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-
    12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,
    1H3
  • Molecular Formula: C22H22ClN5O2S
  • Molecular Structure:CAS No:105219-56-5 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-

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105219-56-5 WEB 2086

  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
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References of 1-Propanone,3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-
Title: Apafant
CAS Registry Number: 105219-56-5
CAS Name: 4-[3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxopropyl]morpholine
Synonyms: 3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-(4-morpholinyl)-1-propanone
Manufacturers' Codes: WEB-2086
Molecular Formula: C22H22ClN5O2S
Molecular Weight: 455.96
Percent Composition: C 57.95%, H 4.86%, Cl 7.78%, N 15.36%, O 7.02%, S 7.03%
Literature References: Platelet activating factor (PAF) antagonist. Prepn: K. H. Weber et al, DE 3502392; eidem, US 5082839 (1986, 1992 both to Boehringer, Ing.). Pharmacology: J. Casals-Stenzel et al., J. Pharmacol. Exp. Ther. 241, 974 (1987). Clinical pharmacology, pharmacokinetics: H. M. Brecht et al., Arzneim.-Forsch. 41, 51 (1991). Clinical effect vs PAF-induced bronchoconstriction: W. S. Adamus et al., Clin. Pharmacol. Ther. 47, 456 (1990).
Properties: Viscous, almost colorless oil. LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel).
Toxicity data: LD50 in mice (mg/kg): 540 i.v.; 4600 orally (Casals-Stenzel)
Use: Tool to evaluate the role of PAF in exptl models of human disease.