Home > Name List By 5 > 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2- methoxybenzenesulfonamide

CAS No 106133-20-4 , 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-
methoxybenzenesulfonamide

  • Name: 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-
    methoxybenzenesulfonamide
  • Synonyms: Tamsulosine; Tamsulosine [INN-French]; Tamsolusin;Flomax; Tamsulosinum; Tamsulosinum [INN-Latin]; 106133-20-4; Tamsulosina;5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-
    methoxybenzenesulfonamide;
  • CAS Registry Number:
  • Melting Point: 226-228 ºC
  • Density: 1.191 g/cm3
  • Refractive index: 1.553
  • Water Solubility: sparingly soluble in water and in methanol
  • Molecular Weight: 408.51172
  • InchiKey: DRHKJLXJIQTDTD-OAHLLOKOSA-N
  • InChI: InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-
    10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,
    23,24)/t15-/m1/s1
  • Molecular Formula: C20H28N2O5S
  • Molecular Structure:CAS No:106133-20-4 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-<br />methoxybenzenesulfonamide

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References of 5-[(2R)-2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-
methoxybenzenesulfonamide
Title: Tamsulosin
CAS Registry Number: 106133-20-4
CAS Name: 5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide
Synonyms: amsulosin
Molecular Formula: C20H28N2O5S
Molecular Weight: 408.51
Percent Composition: C 58.80%, H 6.91%, N 6.86%, O 19.58%, S 7.85%
Literature References: Specific a1-adrenoceptor antagonist. Prepn: K. Imai et al., EP 34432; eidem, US 4703063 (1981, 1987 both to Yamanouchi). Comparative pharmacology of enantiomers and racemate: K. Honda et al., Arch. Pharmacol. 336, 295 (1987). HPLC determn in plasma: Y. Soeishi et al., J. Chromatogr. 533, 291 (1990). Clinical trials in benign prostatic hypertrophy: K. Kawabe et al., J. Urol. 144, 908 (1990); P. Abrams et al., Br. J. Urol. 76, 325 (1995). Review of pharmacology and clinical experience in urological disorders: M. C. Michel, J. J. de la Rosette, Expert Opin. Pharmacother. 5, 151-160 (2004).
 
Derivative Type: Hydrochloride
CAS Registry Number: 106463-17-6
Manufacturers' Codes: LY-253351; YM-12617-1; YM-617
Trademarks: Flomax (Astellas); Flomaxtra (Astellas); Harnal (Astellas); Omnic (Astellas); Pradif (Boehringer, Ing.)
Molecular Formula: C20H28N2O5S.HCl
Molecular Weight: 444.97
Percent Composition: C 53.98%, H 6.57%, N 6.30%, O 17.98%, S 7.21%, Cl 7.97%
Properties: mp 228-230°. [a]D24 -4.0° (c = 0.35 in methanol).
Melting point: mp 228-230°
Optical Rotation: [a]D24 -4.0° (c = 0.35 in methanol)
 
Therap-Cat: In treatment of benign prostatic hypertrophy.
Keywords: a-Adrenergic Blocker; Antiprostatic Hypertrophy.