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CAS No 1066-17-7 , colistin Search by region : Germany

  • Name: colistin
  • Synonyms: kangdisu;colistin;-COLISTIN; coly-mycin; kolimitsin; colimycin; colisticina; colymysins; colomycin;
  • CAS Registry Number:
  • Transport: 3249
  • Flash Point: 883.3°C
  • Boiling Point: 1536.8°Cat760mmHg
  • Density: 1.25g/cm3
  • Refractive index: 1.573
  • Safety Statements: Poison by subcutaneous, intravenous and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 883.3°C
  • EINECS: 213-907-3
  • Molecular Weight: 1155.43
  • InChI: InChI=1/C53H100N16O13/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77)/t30?,31-,32-,33+,34+,35+,36+,37+,38+,39+,40-,42+,43+/m1/s1
  • Molecular Formula: C52H98N16O13
  • Molecular Structure:CAS No:1066-17-7 colistin

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1066-17-7 Colistin

  • Colistin
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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1066-17-7 COLISTINE SULPHATE

  • Germany Cfm Oskar Tropitzsch [Manufacturer]
  • Tel: +49-9231-9619-0
  • Fax: +49-9231-9619-60
  • Address: Cfm Oskar Tropitzsch
    Waldershofer Str. 49-51
    95615 Marktredwitz
    Germany null,nullGermany
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References of colistin
Title: Colistin
CAS Registry Number: 1066-17-7
Synonyms: Polymyxin E
Literature References: Cyclic polypeptide antibiotic produced by Bacillus polymyxa subsp. colistinus. Complex mixture of at least 30 components, primarily colistins A and B. Isoln from Japanese soil: Y. Koyama, JP 52 1546 (1952). Identification of colistins A, B and C: T. Suzuki et al., J. Biochem. (Tokyo) 54, 25 (1963). Structure of colistin A: eidem, ibid. 173, 412. Identity of colistin A with polymyxin E1: S. Wilkinson, L. A. Lowe, J. Chem. Soc. 1964, 4107. Synthesis of colistin A: R. O. Studer et al., Helv. Chim. Acta 48, 1371 (1965). Prepn of sodium sulfomethyl derivs and toxicity study: M. Barnett et al., Br. J. Pharmacol. Chemother. 23, 552 (1964). Comparative pharmacology of sulfate and methansulfonate salts: A. A. Al-Khayyat, A. L. Aronson, Chemotherapy (Basel) 19, 82 (1973). HPLC determn in medicated animal feeds: B. Cancho-Grande et al., Chromatagraphia 54, 481 (2001); in human plasma: J. Li et al., J. Chromatogr. B 761, 167 (2001). Review and comparison with polymyxin B, q.v.: J. Horton, G. A. Pankey, Med. Clin. North Am. 66, 135-142 (1982); M. E. Evans et al, Ann. Pharmacother. 33, 960-967 (1999). Review of clinical experience in cystic fibrosis: J. M. Littlewood et al., Respir. Med. 94, 632 (2000); in treatment of multi-resistant bacterial infections: J. Li et al., Int. J. Antimicrob. Ag. 25, 11-25 (2005).
 
Derivative Type: Colistin sodium methanesulfonate
CAS Registry Number: 8068-28-8
Synonyms: Colistimethate sodium
Trademarks: Alficetin (BMS); Colimicina (UCB); Colimycine (Sanofi-Aventis); Colomycin (Forest); Coly-Mycin M (Monarch); Methacolimycin (Kayaku); Promixin (Profile)
Molecular Formula: C58H105N16Na5O28S5
Molecular Weight: 1749.82
Percent Composition: C 39.81%, H 6.05%, N 12.81%, Na 6.57%, O 25.60%, S 9.16%
Properties: Prepd by treating colistin complex with formaldehyde and sodium bisulfite. Sol in water and stable in the dry form. LD50 i.v. in mice: >550 mg/kg (Barnett).
Toxicity data: LD50 i.v. in mice: >550 mg/kg (Barnett)
 
Derivative Type: Sulfate
CAS Registry Number: 1264-72-8
Trademarks: Belcomycine (Sanofi-Aventis); Colomycin (tabl.) (Forest)
 
Derivative Type: Colistin A
CAS Registry Number: 7722-44-3
CAS Name: Polymyxin E1
Molecular Formula: C53H100N16O13
Molecular Weight: 1169.46
Percent Composition: C 54.43%, H 8.62%, N 19.16%, O 17.79%
Properties: [a]225461 -93.3° (2% acetic acid).
Optical Rotation: [a]225461 -93.3° (2% acetic acid)
 
Derivative Type: Colistin B
CAS Registry Number: 7239-48-7
CAS Name: Polymyxin E2
Molecular Formula: C52H98N16O13
Molecular Weight: 1155.43
Percent Composition: C 54.05%, H 8.55%, N 19.40%, O 18.00%
Properties: [a]225461 -94.5° (2% acetic acid).
Optical Rotation: [a]225461 -94.5° (2% acetic acid)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides.