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CAS No 106941-25-7 , 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid

  • Name: 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
  • Synonyms: GS-0393; GS 393;2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid; GS 0393; 9-(2-Phosphonylmethoxyethyl)adenine; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid;106941-25-7;
  • CAS Registry Number:
  • Melting Point: >260 ºC
  • Flash Point: 336.3ºC
  • Boiling Point: 632.5ºCat 760 mmHg
  • Density: 1.88
  • Flash Point: 336.3ºC
  • Molecular Weight: 273.185742
  • InchiKey: SUPKOOSCJHTBAH-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,
    15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)
  • Molecular Formula: C8H12N5O4P
  • Molecular Structure:CAS No:106941-25-7 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid

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References of 2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid
Title: Adefovir
CAS Registry Number: 106941-25-7
CAS Name: [[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid
Synonyms: 9-(2-phosphonylmethoxyethyl)adenine; PMEA
Manufacturers' Codes: GS-393
Molecular Formula: C8H12N5O4P
Molecular Weight: 273.19
Percent Composition: C 35.17%, H 4.43%, N 25.64%, O 23.43%, P 11.34%
Literature References: Acyclic nucleoside phosphonate (ANP) analog. Prepn: A. Holy, I. Rosenberg, EP 206459; eidem, US 4808716 (1986, 1989 both to Ceskoslov. Akad. Ved); eidem, Collect. Czech. Chem. Commun. 52, 2801 (1987); of dipivoxil ester prodrug: J. E. Starrett, Jr. et al., EP 481214 (1992 to Bristol-Myers Squibb); eidem, US 5663159 (1997 to Inst. Org. Chem. Biochem. Acad. Sci. Czech Rep.; Rega). Crystal structure: C. H. Schwalbe et al., J. Chem. Soc. Perkin Trans. 1 1991, 1348. HPLC determn: P. Augustijns et al., J. Liq. Chromatogr. Relat. Technol. 19, 2271 (1996). Clinical pharmacokinetics: K. C. Cundy et al., Antimicrob. Agents Chemother. 39, 2401 (1995). Review of pharmacology and therapeutic potential: L. Naesens et al., Antiviral Chem. Chemother. 8, 1-23 (1997). Clinical trial in HIV infected patients: J. Kahn et al., J. Am. Med. Assoc. 282, 2305 (1999); in hepatitis B virus (HBV): R. J. C. Gilson et al, J. Viral Hepat. 6, 387 (1999). Resistance surveillance in HBV infections: H. Yang et al., Hepatology 36, 464 (2002).
Properties: Off-white crystalline solid, mp >250°. pKa1 2.0, pKa2 6.8. uv max (H2O) 208, 260 nm (e 19600, 14100); (0.1N HCl) 210, 260 nm (e 19000, 13700); (0.1N NaOH) 216, 262 nm (e 9600, 14500).
Melting point: mp >250°
pKa: pKa1 2.0, pKa2 6.8
Absorption maximum: uv max (H2O) 208, 260 nm (e 19600, 14100); (0.1N HCl) 210, 260 nm (e 19000, 13700); (0.1N NaOH) 216, 262 nm (e 9600, 14500)
 
Derivative Type: Di(pivaloyloxymethyl) ester
CAS Registry Number: 142340-99-6
Synonyms: Adefovir dipivoxil; bis(POM)-PMEA
Manufacturers' Codes: GS-840
Trademarks: Hepsera (Gilead); Preveon (Gilead)
Molecular Formula: C20H32N5O8P
Molecular Weight: 501.47
Percent Composition: C 47.90%, H 6.43%, N 13.97%, O 25.52%, P 6.18%
Properties: Off-white crystalline powder. Soly in water (mg/ml): 19 (pH 2.0); 0.4 (pH 7.2). Log P (octanol/aq phosphate buffer): 1.91.
Log P: Log P (octanol/aq phosphate buffer): 1.91
 
Therap-Cat: Antiviral.
Keywords: Antiviral; Purines/Pyrimidinones.