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CAS No 107667-60-7 , Polaprezinc

  • Name: Polaprezinc
  • Synonyms: Zinc N-(3-aminopropionyl)histidine; Zinc L-carnosine complex;Polaprezinc;
  • CAS Registry Number:
  • Density: g/cm3
  • Safety Statements: A poison by intraperitoneal route. Moderately toxic by ingestion and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and Zn.
  • Molecular Weight: 289.61
  • InChI: InChI=1/C9H13N4O3.Zn/c10-2-1-8(14)13-7(9(15)16)3-6-4-11-5-12-6;/h4-5,7,10H,1-3H2,(H3,11,12,13,14,15,16);/q-1;+3/p-2/rC9H13N4O3Zn/c14-8(1-2-12-17)13-7(9(15)16)3-6-4-10-5-11-6/h4-5,7,12H,1-3H2,(H3,10,11,13,14,15,16)/q+2/p-2
  • Molecular Formula: C9H12N4O3Zn
  • Molecular Structure:CAS No:107667-60-7 Polaprezinc

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References of Polaprezinc
Title: Polaprezinc
CAS Registry Number: 107667-60-7
CAS Name: [N-b-Alanyl-L-histidinato(2-)-N,NN,Oa]zinc
Synonyms: catena-(S)-[m-[Na-(3-aminopropionyl)-L-histidinato(2-)-N1,N2,O:Nt]zinc]; zinc L-carnosine; b-alanyl-L-histidinato zinc; N-(3-aminopropionyl)-L-histidinato zinc
Manufacturers' Codes: Z-103
Trademarks: Promac (Zeria)
Literature References: Polymeric zinc(II) complex with L-carnosine, corresponding to the formula, (C9H12N4O3Zn)n. Exhibits antioxidant and gastroprotective properties. Prepn of crystalline complex: T. Matsukura et al., EP 303380; eidem, US 4981846 (1989, 1991 both to Hamari). Prepn and structure elucidation: T. Matsukura et al., Chem. Pharm. Bull. 38, 3140 (1990). Pharmacology: T. Arakawa et al., Dig. Dis. Sci. 35, 559 (1990). Mechanism of action study: T. Yoshikawa et al., Biochim. Biophys. Acta 1115, 15 (1991). Series of articles on metabolism: Arzneim.-Forsch. 41, 965-995 (1991); on toxicology: ibid. 1033-1057. Acute toxicity: K. Matsuda et al., ibid. 1033.
Properties: White or pale yellow crystalline powder. Insol in water and common organic solvents. LD50 in male, female mice, rats (mg/kg): 220, 165, 405, 422 i.p.; 758, 874, >5000, >5000 s.c.; 1269, 1331, 8441, 7375 orally (Matsuda).
Toxicity data: LD50 in male, female mice, rats (mg/kg): 220, 165, 405, 422 i.p.; 758, 874, >5000, >5000 s.c.; 1269, 1331, 8441, 7375 orally (Matsuda)
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).