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CAS No 108050-54-0 , Tilmicosin

  • Name: Tilmicosin
  • CAS Registry Number:
  • Flash Point: 514.2 ºC
  • Boiling Point: 926.6ºC at 760 mmHg
  • Density: 1.18 g/cm3
  • Refractive index: 1.545
  • Flash Point: 514.2 ºC
  • Molecular Weight: 869.15
  • InChI: InChI=1/C46H80N2O13/c1-13-36-33(24-57-46-44(56-12)43(55-11)40(53)31(8)59-46)19-25(2)14-15-34(49)28(5)20-32(16-17-48-22-26(3)18-27(4)23-48)42(29(6)35(50)21-37(51)60-36)61-45-41(54)38(47(9)10)39(52)30(7)58-45/h14-15,19,26-33,35-36,38-46,50,52-54H,13,16-18,20-24H2,1-12H3/b15-14+,25-19+/t26?,27?,28-,29+,30-,31-,32+,33-,35?,36-,38+,39-,40-,41-,42-,43-,44-,45+,46-/m1/s1
  • Molecular Formula: C46H80N2O13
  • Molecular Structure:CAS No:108050-54-0 Tilmicosin

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References of Tilmicosin
Title: Tilmicosin
CAS Registry Number: 108050-54-0
CAS Name: 4A-O-De(2,6-dideoxy-3-C-methyl-a-L-ribo-hexopyranosyl)-20-deoxo-20-(3,5-dimethyl-1-piperidinyl)tylosin
Synonyms: 20-deoxo-20-(3,5-dimethylpiperidin-1-yl)desmycosin
Manufacturers' Codes: EL-870; LY-177370
Trademarks: Micotil (Elanco); Pulmotil (Elanco)
Molecular Formula: C46H80N2O13
Molecular Weight: 869.13
Percent Composition: C 63.57%, H 9.28%, N 3.22%, O 23.93%
Literature References: Macrolide antibiotic; structurally related to tylosin, q.v. Prepd as 85:15 mixture of cis/trans isomers: M. Debono, H. A. Kirst, EP 103465; eidem, US 4820695 (1984, 1989 both to Lilly); M. Debono et al., J. Antibiot. 42, 1253 (1989). In vitro antibacterial activity: E. E. Ose, ibid. 40, 190 (1987). Metabolism and tissue residue studies in cattle: A. L. Donoho et al., ACS Symp. Ser. 503, 158-167 (1992). Trial in treatment of calf pneumonia: E. E. Ose, L. V. Tonkinson, Vet. Rec. 123, 367 (1988). Prophylactic efficacy in bovine respiratory tract disease: D. W. Morck et al., J. Am. Vet. Med. Assoc. 202, 273 (1993).
Properties: uv max: 283 nm (e 22643). pKa￠ (66% DMF): 7.4, 8.5. [a]D23 +12.75° (c = 0.010004 in CHCl3, 5 cm).
pKa: pKa￠ (66% DMF): 7.4, 8.5
Optical Rotation: [a]D23 +12.75° (c = 0.010004 in CHCl3, 5 cm)
Absorption maximum: uv max: 283 nm (e 22643)
Therap-Cat-Vet: Antibacterial.