Home > Name List By 2 > 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]- methylamino]-1H-pyrimidin-6-one

CAS No 108612-45-9 , 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-
methylamino]-1H-pyrimidin-6-one

  • Name: 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-
    methylamino]-1H-pyrimidin-6-one
  • Synonyms: Zolistam;2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-
    methylamino]-1H-pyrimidin-6-one; 108612-45-9; Zolistan; Zolim; Mizolen; Mizolastinum; Mistamine;Mizollen; Mizolastina;
  • CAS Registry Number:
  • Density: 1.34g/cm3
  • Refractive index: 1.682
  • Molecular Weight: 432.493303
  • InchiKey: PVLJETXTTWAYEW-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H25FN6O/c1-29(23-26-13-10-22(32)28-23)19-11-14-30(15-12-19)
    24-27-20-4-2-3-5-21(20)31(24)16-17-6-8-18(25)9-7-17/h2-10,13,19H,11-12,
    14-16H2,1H3,(H,26,28,32)
  • Molecular Formula: C24H25FN6O
  • Molecular Structure:CAS No:108612-45-9 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-<br />methylamino]-1H-pyrimidin-6-one

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References of 2-[[1-[1-[(4-fluorophenyl)methyl]benzimidazol-2-yl]piperidin-4-yl]-
methylamino]-1H-pyrimidin-6-one
Title: Mizolastine
CAS Registry Number: 108612-45-9
CAS Name: 2-[[1-[1-[(4-Fluorophenyl)methyl]-1H-benzimidazol-2-yl]-4-piperidinyl]methylamino]-4(1H)-pyrimidinone
Synonyms: 2-[[1-[1-(p-fluorobenzyl)-2-benzimidazolyl]-4-piperidinyl]methylamino]-4(3H)-pyrimidinone
Manufacturers' Codes: SL-85.0324
Trademarks: Mizollen (Lorex); Zolim (Schwarz)
Molecular Formula: C24H25FN6O
Molecular Weight: 432.49
Percent Composition: C 66.65%, H 5.83%, F 4.39%, N 19.43%, O 3.70%
Literature References: Nonsedating-type histamine H1-receptor antagonist. Prepn: JP Kokai 87 61979; P. Manoury et al., US 4912219 (1987, 1990 both to Synthelabo). Receptor binding study: J. Benavides et al., Arzneim.-Forsch. 45, 551 (1995). HPLC determn in plasma: V. Ascalone et al., J. Chromatogr. 619, 275 (1993). Clinical pharmacokinetics: P. Rosenzweig et al., Ann. Allergy 69, 135 (1992). Effect on psychomotor performance: J. S. Kerr et al., Eur. J. Clin. Pharmacol. 47, 331 (1994). Clinical trial in allergic rhinitis: F. Leynadier et al., Ann. Allergy Asthma Immunol. 76, 163 (1996).
Properties: Crystals from ethanol, mp 217°. Sol in methanol.
Melting point: mp 217°
Therap-Cat: Antihistaminic.
Keywords: Antihistaminic.