Home > Name List By 1 > 1-methyl-N-[(1S, 5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

CAS No 109889-09-0 , 1-methyl-N-[(1S,
5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

  • Name: 1-methyl-N-[(1S,
    5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
  • Synonyms: AC1NR4P1; Sancuso; 109889-09-0; D04370;1-methyl-N-[(1S,
    5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide; BIDD:GT0272;Kevatril; HMS2089P14; C07023;
  • CAS Registry Number:
  • Flash Point: 275.6°C
  • Boiling Point: 532°Cat760mmHg
  • Density: 1.33g/cm3
  • Flash Point: 275.6°C
  • Molecular Weight: 312.40936
  • InchiKey: MFWNKCLOYSRHCJ-AGUYFDCRSA-N
  • InChI: InChI=1S/C18H24N4O/c1-21-13-6-5-7-14(21)11-12(10-13)19-18(23)17-15-8-3-
    4-9-16(15)22(2)20-17/h3-4,8-9,12-14H,5-7,10-11H2,1-2H3,(H,19,23)/t12?,
    13-,14+
  • Molecular Formula: C18H24N4O
  • Molecular Structure:CAS No:109889-09-0 1-methyl-N-[(1S,<br />5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide

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References of 1-methyl-N-[(1S,
5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide
Title: Granisetron
CAS Registry Number: 109889-09-0
CAS Name: 1-Methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide
Molecular Formula: C18H24N4O
Molecular Weight: 312.41
Percent Composition: C 69.20%, H 7.74%, N 17.93%, O 5.12%
Literature References: Specific serotonin (5HT3) receptor antagonist. Prepn: F. D. King, EP 200444; idem, US 4886808 (1986, 1989 both to Beecham). 5HT3 receptor binding study: G. J. Kilpatrick et al., Nature 330, 746 (1987). Series of articles on pharmacology and clinical trials to prevent chemotherapy-induced emesis: Semin. Oncol. 22, Suppl. 10, 1-30 (1995).
 
Derivative Type: Hydrochloride
CAS Registry Number: 107007-99-8
Manufacturers' Codes: BRL-43694A
Trademarks: Kytril (SKB)
Molecular Formula: C18H24N4O.HCl
Molecular Weight: 348.87
Percent Composition: C 61.97%, H 7.22%, N 16.06%, O 4.59%, Cl 10.16%
Properties: White to off-white solid, mp 290-292°. Readily sol in water at 20°.
Melting point: mp 290-292°
 
Therap-Cat: Antiemetic.
Keywords: Antiemetic; Serotonin Receptor Antagonist.