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CAS No 113806-05-6 , OlopatadineOlopatadine

  • Name: OlopatadineOlopatadine
  • Synonyms: 11-((Z)-3-(Dimethyl-amino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid;OlopatadineOlopatadine;
  • CAS Registry Number:
  • Density: 1.221 g/cm3
  • Molecular Weight: 337.42
  • InChI: InChI=1S/C21H23NO3.ClH/c1-22(2)11-5-8-18-17-7-4-3-6-16(17)14-25-20-10-9-15(12-19(18)20)13-21(23)24;/h3-4,6-10,12H,5,11,13-14H2,1-2H3,(H,23,24);1H/b18-8-;
  • Molecular Formula: C21H23NO3
  • Molecular Structure:CAS No:113806-05-6 OlopatadineOlopatadine

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113806-05-6 OLOPATADINE {(11Z)-11-[3-(DIMETHYLAMINO)PROPYLIDENE]-6,11-DIHYDRODIBENZO[B,E]OXEPIN-2-YL}ACETIC ACID

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113806-05-6 Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-

  • China Sainsein Chemical Co., Ltd. [Manufacturers]
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140462-76-6; 113806-05-6 Olopatadine Hydrochloride

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140462-76-6; 113806-05-6 Olopatadine

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113806-05-6 Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-

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113806-05-6 Dibenz[b,e]oxepin-2-aceticacid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-

  • China SHENS International Co., Ltd [Manufacturers]
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References of OlopatadineOlopatadine
Title: Olopatadine
CAS Registry Number: 113806-05-6
CAS Name: (11Z)-11-[3-(Dimethylamino)propylidene]-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
Molecular Formula: C21H23NO3
Molecular Weight: 337.41
Percent Composition: C 74.75%, H 6.87%, N 4.15%, O 14.23%
Literature References: Dual acting histamine H1-receptor antagonist and mast cell stabilizer. Prepn: E. Oshima et al., EP 235796; eidem, US 5116863 (1987, 1992 both to Kyowa); eidem, J. Med. Chem. 35, 2074 (1992). Pharmacology: C. Kamei et al., Arzneim.-Forsch. 45, 1005 (1995); J. M. Yanni et al., J. Ocul. Pharmacol. Ther. 12, 389 (1996). Receptor binding profile: N. A. Sharif et al., J. Pharmacol. Exp. Ther. 278, 1252 (1996). Clinical trial in allergic conjunctivitis: M. B. Abelson, L. Spitalny, Am. J. Ophthalmol. 125, 797 (1998).
Properties: Crystallized as the hemihydrate from 2-propanol + water, mp 188-189.5°.
Melting point: mp 188-189.5°
 
Derivative Type: Hydrochloride
CAS Registry Number: 140462-76-6
Manufacturers' Codes: AL-4943A; KW-4679
Trademarks: Opatanol (Alcon); Patanol (Alcon)
Molecular Formula: C21H23NO3.HCl
Molecular Weight: 373.87
Percent Composition: C 67.46%, H 6.47%, N 3.75%, O 12.84%, Cl 9.48%
Properties: Crystals from acetone-water, mp 248° (dec). Sol in water.
Melting point: mp 248° (dec)
 
Therap-Cat: Antiallergic; antihistaminic.
Keywords: Antihistaminic; Tricyclics; Other Tricyclics.