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CAS No 1143-38-0 , 1,8-dihydroxy-10H-anthracen-9-one

  • Name: 1,8-dihydroxy-10H-anthracen-9-one
  • Synonyms: 1,8-dihydroxy-10H-anthracen-9-one; 1,8-dihydroxy-; 1,8-Dihydroxyanthrone;Dithranol; 1,8-Dihydroxy-9-anthrone; Anthrone; 1143-38-0; Anthra-Derm;
  • CAS Registry Number:
  • Melting Point: 178-181 °C(lit.)
  • Flash Point: 248.6°C
  • Boiling Point: 464.1°Cat760mmHg
  • Density: 1.419g/cm3
  • Refractive index: 1.837
  • Water Solubility: <0.1 g/100 mL at 20 C
  • Safety Statements: A mild skin irritant. When heated to decomposition it emits acrid smoke and irritating vapors.
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 248.6°C
  • EINECS: 214-538-0
  • Molecular Weight: 226.2274
  • InchiKey: NUZWLKWWNNJHPT-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H10O3/c15-10-5-1-3-8-7-9-4-2-6-11(16)13(9)14(17)12(8)10/h1-
    6,15-16H,7H2
  • Risk Statements: R36/37/38
  • Molecular Formula: C14H10O3
  • Molecular Structure:CAS No:1143-38-0 1,8-dihydroxy-10H-anthracen-9-one

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  • CAS # 1143-38-0 Synonyms 1,8-dihydroxy-9-anthrone; 1,8-dihydroxy-anthrone; anthra-derm; anthralin; dithranol; dithrocream; chrysodermol; cygnolin; derobin; psoriacide; psorin; Molecular Formula C14H10O3 Molecular Weight 226.23 Appearance Lemon yellow...
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References of 1,8-dihydroxy-10H-anthracen-9-one
Title: Anthralin
CAS Registry Number: 1143-38-0
CAS Name: 1,8-Dihydroxy-9(10H)-anthracenone
Synonyms: 1,8-dihydroxyanthrone; dithranol
Trademarks: Anthraforte (Stiefel); Anthranol (Stiefel); Anthrascalp (Stiefel); Antraderm (Protea); Cignolin (Bayer); Dithrocream (Dermal); Drithocreme (Dermik); Dritho-Scalp (Dermik); Micanol (Bioglan); Psoradrate (Procter & Gamble); Psoriderm (Istoria)
Molecular Formula: C14H10O3
Molecular Weight: 226.23
Percent Composition: C 74.33%, H 4.46%, O 21.22%
Literature References: Prepn: Y. Hirosé, Ber. 45, 2474 (1912); K. Zahn, H. Koch, ibid. 71B, 172 (1938). Revised structure: H. M. Avdovich, G. A. Neville, Can. J. Spectrosc. 25, 110 (1980); F. R. Ahmed, Acta Crystallogr. B36, 3184 (1980). Historical review: R. E. Ashton et al., J. Am. Acad. Dermatol. 9, 173-192 (1983). Review of mechanism of action: L. Kemény et al., Skin Pharmacol. 3, 1-20 (1990); of clinical pharmacology and efficacy in psoriasis: G. Mahrle, Clin. Dermatol. 15, 723-737 (1997).
Properties: Lemon yellow leaflets or needles from ligroin, mp 176-181°. Practically insol in water. Sol in chloroform, acetone, benzene. Slightly sol in alcohol, ether, glacial acetic acid. Sol in dil NaOH with yellow color and green fluorescence, becoming orange-red on exposure to air.
Melting point: mp 176-181°
Therap-Cat: Antipsoriatic.
Keywords: Antipsoriatic.