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CAS No 115-53-7 , Sinomenine Search by region : China

  • Name: Sinomenine
  • Synonyms: 115-53-7; EINECS 204-094-6; Sabianine A; BRN 0095280;Sinomenine; CCRIS 1550; Sinomenine HCl; Kukoline; Cucoline;Coculine;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 180 °C (dec.)(lit.)
  • Density: 1.3 g/cm3
  • Safety Statements: 53-22-26-36/37/39-45
  • Hazard Symbols: T: Toxic;
  • EINECS: 204-094-6
  • Molecular Weight: 329.39022
  • InchiKey: INYYVPJSBIVGPH-QHRIQVFBSA-N
  • InChI: InChI=1S/C19H23NO4/c1-20-7-6-19-10-14(21)16(24-3)9-12(19)13(20)8-11-4-5-
    15(23-2)18(22)17(11)19/h4-5,9,12-13,22H,6-8,10H2,1-3H3/t12-,13+,
    19-/m1/s1
  • Risk Statements: 45-46-23/24/25-36/37/38
  • Molecular Formula: C19H23NO4
  • Molecular Structure:CAS No:115-53-7 Sinomenine

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115-53-7 sinomenine

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115-53-7 SINOMENINE

  • China NINGBO V&P CHEMISTRY [Manufacturer]
  • Tel: 86-574-27666767
  • Fax: 86-574-56704282
  • Address: 21/F, NO.11 BLDG,XIN TIAN DI,
    NO689, SHI JI ROAD,
    NINGBO,CHINA, 315040 null,nullChina
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115-53-7 SINOMENINE HCL

  • China SINO GREAT ENTERPRISE LTD. [Manufacturer]
  • Tel: +86-731-4427351
  • Fax: +86-731-4429615
  • Address: 154 Jianxiang South Road,
    Changsha, Hunan, China. null,nullChina
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115-53-7 Sinomenine-Botanical reference materials/phytochemicals

  • Sinomenine-Botanical reference materials/phytochemicals
  • China shanghai Tauto Biotech Co., Ltd [Manufacturer]
  • Tel: +86-21-51320588
  • Fax: +86-21-51320502
  • Address: No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA Shanghai,ShanghaiChina
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115-53-7 SINOMENINE HYDROCHLORIDE

  • China Aktin Chemicals, Inc. [Manufacturer]
  • Tel: +86-28-85159085
  • Fax: +86-28-85152372
  • Address: Aktin Chemicals, Inc.
    Yongfeng Plaza, No.52,
    Yongfeng Road, Hi-tech Zone,
    Chengdu 610041
    P.R.China null,nullChina
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115-53-7 Sinomenine

  • China Kouting Chemical Co.,Ltd [Importer/Exporter]
  • Tel: +86-(21)-58116473
  • Fax: +86-(21)-61094103
  • Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318, shanghai,shanghaiChina
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115-53-7 SINOMENINE

  • China Fleton Reference Substance Co.,Ltd [Manufacturer]
  • Tel: 86-28-84400798
  • Fax: +86-28-84400789 85270340
  • Address: Fleton Reference Substance Co.,Ltd
    Floor 2, Huaxiang Mansion,
    No 47, Huaishu Street,
    Chengdu, China
    Zip: 610031 null,nullChina
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115-53-7 Sinomenine

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115-53-7 Sinomenine

  • China CIDIC Co.,Ltd. null
  • Fax: +86-510-82303031
  • Address: 15/F, HODO International Plaza, 531 Zhongshan Road, Wuxi, China null,nullChina
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115-53-7 SINOMENINE HCL

  • China Enze Chemicals Co.,Ltd [Manufacturer]
  • Tel: +(86)-(571)-8865-5925/ +86-013750849205 (mobile)
  • Fax: +(86)-(571)5627-7156
  • Address: Industry develop area Meicheng Town,
    Jiande, H/Z, China null,nullChina
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References of Sinomenine
Title: Sinomenine
CAS Registry Number: 115-53-7
CAS Name: (9a,13a,14a)-7,8-Didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one
Synonyms: cucoline; coculine; kukoline
Molecular Formula: C19H23NO4
Molecular Weight: 329.39
Percent Composition: C 69.28%, H 7.04%, N 4.25%, O 19.43%
Literature References: An optical isomer of methoxythebainone. Configuration at the asymmetric centers, C9, C13, and C14, is the mirror image of those in morphine. From root of Sinomenium acutum (Thunb.) Rehd. & Wils. (Cocculus diversifolius DC.), Menispermaceae: Goto, J. Chem. Soc. Jpn. 44, 795 (1923), C.A. 18, 2710 (1924); Ohta, Kitasato Arch. Exp. Med. 6, 259 (1925), C.A. 21, 32332 (1927). Structure: Kondo, Ochiai, Ann. 470, 224 (1929); Sasaki, Yakugaku Zasshi 80, 270 (1960), C.A. 54, 11702g (1960). Biogenesis: Cohen, Chem. Ind. (London) 1956, 1391. Pharmacology: S. Fu et al., Yao Hsueh Hsueh Pao 10, 673 (1963), C.A. 60, 8525h (1964). Reviews: Holmes in R. H. F. Manske, H. L. Holmes, The Alkaloids vol. II (Academic Press, New York, 1952) pp 219-260; K. W. Bentley, The Chemistry of the Morphine Alkaloids (Oxford, 1954).
Properties: Clusters of needles from benzene, mp 161°. After melting once, the mp is raised to 182°. [a]D26 -71° (c = 2.1 in alc). Sol in alc, acetone, chloroform, dil alkali; slightly sol in water, ether, benzene. LD50 orally in mice: 580 mg/kg (Fu).
Melting point: mp 161°; mp is raised to 182°
Optical Rotation: [a]D26 -71° (c = 2.1 in alc)
Toxicity data: LD50 orally in mice: 580 mg/kg (Fu)
 
Derivative Type: Hydrochloride dihydrate
Molecular Formula: C19H24ClNO4.2H2O
Molecular Weight: 401.88
Percent Composition: C 56.78%, H 7.02%, Cl 8.82%, N 3.49%, O 23.89%
Properties: Long prisms from water, dec 231° when anhydr. [a]D17 -82° (c = 4.4). Sol in about 1.5 parts water.
Optical Rotation: [a]D17 -82° (c = 4.4)