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CAS No 119006-77-8 , 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole

  • Name: 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
  • Synonyms: 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole; 119006-77-8; Flutrimazolum; UR-4056; Flutrimazolum [INN-Latin];Flutrimazol; Flutrimazol [INN-Spanish]; Flutrimazole (INN);
  • CAS Registry Number:
  • Density: 1.15 g/cm3
  • Refractive index: 1.59
  • Molecular Weight: 346.372646
  • InchiKey: QHMWCHQXCUNUAK-UHFFFAOYSA-N
  • InChI: InChI=1S/C22H16F2N2/c23-19-12-10-18(11-13-19)22(26-15-14-25-16-26,
    17-6-2-1-3-7-17)20-8-4-5-9-21(20)24/h1-16H
  • Molecular Formula: C22H16F2N2
  • Molecular Structure:CAS No:119006-77-8 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole

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119006-77-8 Flutrimazole

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119006-77-8 Flutrimazole

  • Flutrimazole, 99.00-101.00%
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References of 1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole
Title: Flutrimazole
CAS Registry Number: 119006-77-8
CAS Name: 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
Synonyms: 1-[o-fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole
Manufacturers' Codes: UR-4056
Trademarks: Micetal (Uriach)
Molecular Formula: C22H16F2N2
Molecular Weight: 346.37
Percent Composition: C 76.29%, H 4.66%, F 10.97%, N 8.09%
Literature References: Prepn: J. Bartroli, M. Anguita, EP 352352; eidem, US 5149707 (1990, 1992 both to Uriach). Series of articles on synthesis, antifungal activity, pharmacokinetics: Arzneim.-Forsch. 42, 832-863 (1992). Toxicity study: M. L. Vericat et al., ibid. 841. Clinical trial in dermatomycoses: O. Binet et al., Mycoses 37, 455 (1994).
Properties: Crystals from acetonitrile, mp 164-167°. Also reported as white solid, mp 161-163°. LD50 in male, female mice, male, female rats (mg/kg): >1000, >1000, 808, 1214 orally; >2000, >2000, 1079, 1446 i.p. (Vericat).
Melting point: mp 164-167°; mp 161-163°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): >1000, >1000, 808, 1214 orally; >2000, >2000, 1079, 1446 i.p. (Vericat)
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic); Imidazoles.