CAS No 1197-18-8 , 4-(aminomethyl)cyclohexane-1-carboxylic acid Search by region : Germany

Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
Synonyms: Tranhexamic acid; Anvitoff; Tamcha;Cyklokapron; Ugurol; Trans AMCHA; Tranexamsaeure;4-(aminomethyl)cyclohexane-1-carboxylic acid; Transamin;
CAS Registry Number:1197-18-8
Transport: 25kgs
Density: 1.096 g/cm³
Water Solubility: 1g/6ml
Safety Statements: R36/37/38,
Hazard Symbols: Xi:Irritant;
EINECS: 214-818-2
Molecular Weight: 157.2102
InchiKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
Risk Statements: S26,S37/39,
Molecular Formula: C₈H₁₅NO₂
Molecular Structure:

Related products

Select to

          
           1197-18-8 TRANS-4-(AMINOMETHYL)CYCLOHEXANECARBOXYLIC ACID; 97%
           
             ABCR GmbH & Co KG
             
              [Manufacturer]
Tel:  +49 721 95061-0
Fax:  +49 721 95061-80
Address: Im Schlehert 10 
76187 Karlsruhe 
Germany null,nullGermany

           1197-18-8 TRANS-4-AMINOMETHYLCYCLOHEXANECARBOXYLIC ACID = TRANS-4-(AMINOMETHYL)CYCLOHEXANCARBOXYLIC ACID = TRANEXAMIC ACID
           
             CHEMOS GmbH
             
              [Manufacturer]
Tel:  0049 9402/9336 0
Fax:  0049 9402/9336 13
Address: CHEMOS GmbH 
Werner-von-Siemensstr. 3 
93128 Regenstauf 
Germany null,nullGermany

           1197-18-8 TRANEXAMIC ACID
           
             Cfm Oskar Tropitzsch
             
              [Manufacturer]
Tel:  +49-9231-9619-0
Fax:  +49-9231-9619-60
Address: Cfm Oskar Tropitzsch
Waldershofer Str. 49-51
95615 Marktredwitz
Germany null,nullGermany

           1197-18-8 TRANEXAMIC ACID
           
             Beckmann-Kenko GmbH
             
              [Manufacturer]
Tel:  +49 4241 9308-88
Fax:  +49 4241 9308-89
Address: Beckmann-Kenko GmbH 
AUF DEM SCHEUNENBRINK 8 
D-27211 BASSUM, GERMANY null,nullGermany

Select to

1/1

References of 4-(aminomethyl)cyclohexane-1-carboxylic acid

Title: Tranexamic Acid
CAS Registry Number: 1197-18-8
CAS Name: trans-4-(Aminomethyl)cyclohexanecarboxylic acid
Synonyms: AMCHA
Manufacturers' Codes: RP-18429
Trademarks: Anvitoff (Abbott); Cyklokapron (Pfizer); Exacyl (Sanofi-Synthelabo); Spiramin (Mitsui); Spotof (CCD); Tranex (Lusofarmaco); Transamin (Daiichi); Ugurol (Rottapharm)
Molecular Formula: C8H15NO2
Molecular Weight: 157.21
Percent Composition: C 61.12%, H 9.62%, N 8.91%, O 20.35%
Literature References: Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Prepn: A. Einhorn, C. Ladisch, Ann. 310, 194 (1900); M. Levine, R. Sedlecky, J. Org. Chem. 24, 115 (1959); NL 6503605; T. Naito et al., US 3499925 (1965, 1970 to both Daiichi Seiyaku and Mitsubishi Chem.). Pharmacology: Andersson et al., Scand. J. Haematol. 2, 230 (1965). Resoln of isomers and antiplasmin activity: M. Shimizu et al., Chem. Pharm. Bull. 16, 357 (1968), T. Naito et al., ibid., 728. Toxicity data: B. Melander et al., Acta Pharmacol. Toxicol. 22, 340 (1965). Clinical study in treatment of acute upper gastrointestinal tract bleeding: D. Barer et al., N. Engl. J. Med. 308, 1571 (1983); in menorrhagia: J. Bonnar, B. L. Sheppard, Br. Med. J. 313, 579 (1996). Review of pharmacology and therapeutic use: C. J. Dunn, K. L. Goa, Drugs 57, 1005-1032 (1999).
Properties: mp 386-392° (dec). Soly in water: about 1 g/6 ml. Very slightly sol in alcohol, ether. Practically insol in most other organic solvents. Chemically stable; not hygroscopic. LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander).
Melting point: mp 386-392° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)

Derivative Type: cis-form
CAS Registry Number: 1197-17-7
Properties: mp 236-238° (dec).
Melting point: mp 236-238° (dec)

Therap-Cat: Hemostatic.
Keywords: Hemostatic.