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CAS No 1197-18-8 , 4-(aminomethyl)cyclohexane-1-carboxylic acid Search by region : Japan

  • Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
  • Synonyms: Tranhexamic acid; Anvitoff; Tamcha;Cyklokapron; Ugurol; Trans AMCHA; Tranexamsaeure;4-(aminomethyl)cyclohexane-1-carboxylic acid; Transamin;
  • CAS Registry Number:
  • Transport: 25kgs
  • Density: 1.096 g/cm3
  • Water Solubility: 1g/6ml
  • Safety Statements: R36/37/38,
  • Hazard Symbols: Xi:Irritant;
  • EINECS: 214-818-2
  • Molecular Weight: 157.2102
  • InchiKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
  • InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
  • Risk Statements: S26,S37/39,
  • Molecular Formula: C8H15NO2
  • Molecular Structure:CAS No:1197-18-8 4-(aminomethyl)cyclohexane-1-carboxylic acid

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1197-18-8 tranexamic acid

  • Japan Nacalai Tesque, Inc. [Manufacturers]
  • Tel: 81 75 251 1723 81-75-251-1730
  • Fax: 81-75-251-1763
  • Address: Nijo Karasuma, Nakagyo-ku Kyoto 604-0855 Japan Nakagyo-ku,KyotoJapan
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1197-18-8 tranexamic acid

  • Japan Kanto Chemical Co., Inc. [Manufacturers]
  • Tel: +81 3 3663 7631
  • Fax: +81 3 3667 8277
  • Address: 2-8, Nihonbashi Honcho 3-chome,Chuo-ku, Tokyo, 103-0023, Japan Tokyo,TokyoJapan
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References of 4-(aminomethyl)cyclohexane-1-carboxylic acid
Title: Tranexamic Acid
CAS Registry Number: 1197-18-8
CAS Name: trans-4-(Aminomethyl)cyclohexanecarboxylic acid
Synonyms: AMCHA
Manufacturers' Codes: RP-18429
Trademarks: Anvitoff (Abbott); Cyklokapron (Pfizer); Exacyl (Sanofi-Synthelabo); Spiramin (Mitsui); Spotof (CCD); Tranex (Lusofarmaco); Transamin (Daiichi); Ugurol (Rottapharm)
Molecular Formula: C8H15NO2
Molecular Weight: 157.21
Percent Composition: C 61.12%, H 9.62%, N 8.91%, O 20.35%
Literature References: Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Prepn: A. Einhorn, C. Ladisch, Ann. 310, 194 (1900); M. Levine, R. Sedlecky, J. Org. Chem. 24, 115 (1959); NL 6503605; T. Naito et al., US 3499925 (1965, 1970 to both Daiichi Seiyaku and Mitsubishi Chem.). Pharmacology: Andersson et al., Scand. J. Haematol. 2, 230 (1965). Resoln of isomers and antiplasmin activity: M. Shimizu et al., Chem. Pharm. Bull. 16, 357 (1968), T. Naito et al., ibid., 728. Toxicity data: B. Melander et al., Acta Pharmacol. Toxicol. 22, 340 (1965). Clinical study in treatment of acute upper gastrointestinal tract bleeding: D. Barer et al., N. Engl. J. Med. 308, 1571 (1983); in menorrhagia: J. Bonnar, B. L. Sheppard, Br. Med. J. 313, 579 (1996). Review of pharmacology and therapeutic use: C. J. Dunn, K. L. Goa, Drugs 57, 1005-1032 (1999).
Properties: mp 386-392° (dec). Soly in water: about 1 g/6 ml. Very slightly sol in alcohol, ether. Practically insol in most other organic solvents. Chemically stable; not hygroscopic. LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander).
Melting point: mp 386-392° (dec)
Toxicity data: LD50 in mice, rats (mg/kg): 1500, 1200 i.v. (Melander)
 
Derivative Type: cis-form
CAS Registry Number: 1197-17-7
Properties: mp 236-238° (dec).
Melting point: mp 236-238° (dec)
 
Therap-Cat: Hemostatic.
Keywords: Hemostatic.