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CAS No 120014-06-4 , 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

  • Name: 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
  • Synonyms: Donepezil [INN:BAN]; 120014-06-4; Donaz (TN); Spectrum_001664; Aricept ODT; CHEBI:53289;Eranz;2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one; Donepezil (INN);
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 207 ºC
  • Flash Point: 273.1ºC
  • Boiling Point: 527.9ºCat760mmHg
  • Density: 1.141g/cm3
  • Refractive index: 1.578
  • Water Solubility: 2.931 MG/L
  • Safety Statements: 26-36
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 273.1ºC
  • Molecular Weight: 379.49196
  • InchiKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N
  • InChI: InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-
    8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
  • Risk Statements: 36/37/38
  • Molecular Formula: C24H29NO3
  • Molecular Structure:CAS No:120014-06-4 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one

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120014-06-4 Donepezil

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120014-06-4 DONEPEZIL-D4.HCL

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120014-06-4 5,6-Dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1 H-inden-1-one

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120014-06-4 5,6-dimethoxy-2-(Pyridine-4-yl)methylene-indan-1-one

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References of 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Title: Donepezil
CAS Registry Number: 120014-06-4
CAS Name: 2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
Synonyms: 5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-2,3-dihydro-1H-inden-1-one; 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine
Molecular Formula: C24H29NO3
Molecular Weight: 379.49
Percent Composition: C 75.96%, H 7.70%, N 3.69%, O 12.65%
Literature References: Acetylcholinesterase inhibitor. Prepn: H. Sugimoto et al., EP 296560, eidem, US 4895841 (1988, 1990 both to Eisai). Synthesis: Y. Iimura et al., J. Labelled Compd. Radiopharm. 27, 835 (1989). Resolution of enantiomers: J. Haginaka, C. Seyama, J. Chromatogr. B 577, 95 (1992). Clinical pharmacokinetics: A. Ohnishi et al., J. Clin. Pharmacol. 33, 1086 (1993). Clinical trials in Alzheimer's disease: R. C. Mohs et al., Neurology 57, 481 (2001); B. Winblad et al., ibid. 489. Review of pharmacology and clinical experience in cognitive disorders: G. C. Román, S. J. Rogers, Expert Opin. Pharmacother. 5, 161-180 (2004).
 
Derivative Type: Hydrochloride
CAS Registry Number: 120011-70-3
Manufacturers' Codes: E-2020
Trademarks: Aricept (Eisai)
Molecular Formula: C24H29NO3.HCl
Molecular Weight: 415.95
Percent Composition: C 69.30%, H 7.27%, N 3.37%, O 11.54%, Cl 8.52%
Properties: Crystals from methanol/IPE, mp 211-212° (dec).
Melting point: mp 211-212° (dec)
 
Therap-Cat: Nootropic.
Keywords: Nootropic.