Home > Name List By 2 > 2-[3-(2-cyanopropan-2-yl)-5-(1,2, 4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

CAS No 120511-73-1 , 2-[3-(2-cyanopropan-2-yl)-5-(1,2,
4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile

  • Name: 2-[3-(2-cyanopropan-2-yl)-5-(1,2,
    4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
  • Synonyms: Anastrozol; anastrazole; ICI D1033; Zeneca ZD 1033;2-[3-(2-cyanopropan-2-yl)-5-(1,2,
    4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile; ZD-1033; Anastrole;Arimidex; 120511-73-1; Asiolex;
  • CAS Registry Number:
  • Transport: OTH
  • Flash Point: 469.7 ºC at 760 mmHg
  • Boiling Point: 469.7 ºC at 760 mmHg
  • Density: 1.08 g/cm3
  • Refractive index: 1.791
  • Safety Statements: S26;S37/39;
  • Hazard Symbols: Xi
  • Flash Point: 469.7 ºC at 760 mmHg
  • Molecular Weight: 293.36626
  • InchiKey: YBBLVLTVTVSKRW-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H19N5/c1-16(2,
    9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,
    1-4H3
  • Risk Statements: 36/37/38
  • Molecular Formula: C17H19N5
  • Molecular Structure:CAS No:120511-73-1 2-[3-(2-cyanopropan-2-yl)-5-(1,2,<br />4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
References of 2-[3-(2-cyanopropan-2-yl)-5-(1,2,
4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
Title: Anastrozole
CAS Registry Number: 120511-73-1
CAS Name: a,a,a¢,a¢-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile
Synonyms: 2,2¢-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)
Manufacturers' Codes: ZD-1033; ICI-D-1033
Trademarks: Arimidex (AstraZeneca)
Molecular Formula: C17H19N5
Molecular Weight: 293.37
Percent Composition: C 69.60%, H 6.53%, N 23.87%
Literature References: Aromatase inhibitor. Prepn: P. N. Edwards, M. S. Large, EP 296749; eidem, US 4935437 (1989, 1990 both to ICI). Reviews of pharmacology, clinical pharmacokinetics: P. V. Plourde et al., Breast Cancer Res. Treat. 30, 103-111 (1994); idem et al., J. Steroid Biochem. Mol. Biol. 53, 175-179 (1995). Clinical trial in advanced breast cancer: A. U. Buzdar et al., Cancer 79, 730 (1997).
Properties: Crystals from ethyl acetate/cyclohexane, mp 81-82°.
Melting point: mp 81-82°
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic (Hormonal); Aromatase Inhibitors; Aromatase Inhibitors.