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CAS No 121679-13-8 , N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide Search by region : Canada

  • Name: N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
  • Synonyms: CHEBI:7478;N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide; Amerge;Naramig; naratriptanum; 121679-13-8; N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide; Colatan;
  • CAS Registry Number:
  • Melting Point: 335.464
  • Flash Point: 281.2°C
  • Boiling Point: 541.3°C at 760 mmHg
  • Density: 1.227g/cm3
  • Refractive index: 1.605
  • Flash Point: 281.2°C
  • Molecular Weight: 335.4643
  • InchiKey: AMKVXSZCKVJAGH-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H25N3O2S/c1-18-23(21,
    22)10-7-13-3-4-17-15(11-13)16(12-19-17)14-5-8-20(2)9-6-14/h3-4,11-12,14,
    18-19H,5-10H2,1-2H3
  • Molecular Formula: C17H25N3O2S
  • Molecular Structure:CAS No:121679-13-8 N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide

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121679-13-8 NARATRIPTAN

  • Canada TLC PharmaChem., Inc. [Manufacturer]
  • Tel: 905-760-1098
  • Fax: 905-760-2098
  • Address: TLC PharmaChem., Inc.
    5-150 Connie Crescent
    Concord, Ontario
    L4K 1L9, Canada null,nullCanada
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References of N-methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethanesulfonamide
Title: Naratriptan
CAS Registry Number: 121679-13-8
CAS Name: N-Methyl-3-(1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide
Molecular Formula: C17H25N3O2S
Molecular Weight: 335.46
Percent Composition: C 60.87%, H 7.51%, N 12.53%, O 9.54%, S 9.56%
Literature References: Serotonin 5-HT1B/1D receptor agonist. Prepn: A. W. Oxford et al., EP 303507; eidem, US 4997841 (1989, 1991 both to Glaxo). Pharmacology and receptor binding study: H. E. Connor et al., Cephalalgia 17, 145 (1997). Determn in plasma and pharmacokinetics in rabbits: B. D. Duléry et al., J. Pharm. Biomed. Anal. 15, 1009 (1997). Clinical trial in migraine: H. Havanka et al., Clin. Ther. 22, 970 (2000).
Properties: Crystals from ethyl acetate, mp 170-171°.
Melting point: mp 170-171°
 
Derivative Type: Hydrochloride
CAS Registry Number: 143388-64-1
Manufacturers' Codes: GR-85548A
Trademarks: Amerge (GSK); Naramig (GSK)
Molecular Formula: C17H25N3O2S.HCl
Molecular Weight: 371.93
Percent Composition: C 54.90%, H 7.05%, N 11.30%, O 8.60%, S 8.62%, Cl 9.53%
Properties: Microcrystals, mp 237-239°.
Melting point: mp 237-239°
 
Therap-Cat: Antimigraine.
Keywords: Antimigraine; Serotonin Receptor Agonist.