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CAS No 12244-57-4 , Sodium aurothiomalate Search by region : China

  • Name: Sodium aurothiomalate
  • Synonyms: sodium aurothiomalate hydrate; disodium 2-(auriothio)succinate;(1,2-Dicarboxyethylthio)gold disodium salt; Gold sodium Thiomalate;Sodium aurothiomalate;
  • CAS Registry Number:
  • Safety Statements: R20/21/22;R43
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 235-479-7
  • Molecular Weight: 390.07
  • InChI: InChI=1/C4H6O4S.Au.2Na/c5-3(6)1-2(9)4(7)8;;;/h2,9H,1H2,(H,5,6)(H,7,8);;;/q;3*+1/p-3/rC4H5AuO4S.2Na/c5-10-2(4(8)9)1-3(6)7;;/h2H,1H2,(H,6,7)(H,8,9);;/q;2*+1/p-2
  • Risk Statements: S36
  • Molecular Formula: C4H3AuNa2O4S
  • Molecular Structure:CAS No:12244-57-4 Sodium aurothiomalate

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12244-57-4 SODIUM AUROTHIOMALATE(I)

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References of Sodium aurothiomalate
Title: Gold Sodium Thiomalate
CAS Registry Number: 12244-57-4
CAS Name: Mercaptobutanedioic acid monogold(1+) sodium salt
Synonyms: sodium aurothiomalate
Trademarks: Myochrysine (Merck & Co.); Shiosol (Shionogi); Tauredon (Byk Gulden)
Literature References: Disease modifying antirheumatic drug (DMARD). Mixture of the mono- (C4H4AuNaO4S) and disodium (C4H3AuNa2O4S) salts of gold thiomalic acid. Prepn as the monohydrate of the disodium salt: M. Delépine, US 1994213 (1935 to Rhone Poulenc). Detection in blood by atomic absorption spectroscopy: A. I. A. Rodgers et al., Anal. Proc. 19, 87 (1982). Clinical pharmacokinetics: K. L. N. Blocka et al., Clin. Pharmacokinet. 11, 133 (1986). Discussion of mechanisms of action: H. A. Capell, Agents Actions Suppl. 24, 158 (1988). Clinical trial in rheumatoid arthritis: R. Munro et al., Ann. Rheum. Dis. 57, 88 (1998).
Properties: White to yellowish-white powder, metallic taste. Very sol in water. Practically insol in alcohol, ether. Aq solns are colorless to pale yellow. pH of a 5% aq soln: 5.8-6.5.
Therap-Cat: Antirheumatic.
Keywords: Antiarthritic/Antirheumatic.