Home > Name List By 3 > 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CAS No 123524-52-7 , 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

  • Name: 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
    2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Synonyms: CS-905; RS-9054; Azalnidipine; Calblock; NCGC00167436-01;3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
    2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;123524-52-7; Azelnidipine [INN]; CS 905; AG-D-50614;
  • CAS Registry Number:
  • Flash Point: 709.3ºCat 760 mmHg
  • Boiling Point: 709.3ºCat 760 mmHg
  • Density: 1.33 g/cm3
  • Refractive index: 1.658
  • Safety Statements: 26-39
  • Hazard Symbols: Xn
  • Flash Point: 709.3ºCat 760 mmHg
  • Molecular Weight: 582.64626
  • InchiKey: ZKFQEACEUNWPMT-UHFFFAOYSA-N
  • InChI: InChI=1S/C33H34N4O6/c1-20(2)42-32(38)27-21(3)35-31(34)29(28(27)24-15-10-
    16-25(17-24)37(40)41)33(39)43-26-18-36(19-26)30(22-11-6-4-7-12-22)23-13-
    8-5-9-14-23/h4-17,20,26,28,30,35H,18-19,34H2,1-3H3
  • Risk Statements: 22-41
  • Molecular Formula: C33H34N4O6
  • Molecular Structure:CAS No:123524-52-7 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl<br />2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
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123524-52-7 Azelnidipine

  • Azelnidipine
  • United States RIA International [Manufacturer]
  • Tel: 19735811282
  • Fax: 19735811283
  • Address: 11 Melanie Lane #17 East Hanover 07936 NJ UNITED STATES NJ,nullUnited States
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123524-52-7 Azelnidipine

  • China China Langchem Inc. null
  • Tel: +86-(21)-58956006
  • Fax: +86-(21)-58956100
  • Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203, null,nullChina
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123524-52-7 Azelnidipine

  • China Haihang Industry Co., Ltd. null
  • Tel: +86-(531)-88032799
  • Fax: +86-(531)-85821093
  • Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100, null,nullChina
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123524-52-7 Azelnidipine

  • Azelnidipine, 99%
  • China henglidahuagong co,.Ltd [Manufacturer]
  • Tel: 13996793719
  • Fax: 86+(0535?2260023
  • Address: NO 238,CANAN ROAD NORTH OF WENCANG,LAIZHOU CITY,SHANGDONG,CHINA LAIZHOU CITYCHINA LAIZHOU CITY,nullChina
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123524-52-7 AZELNIDIPINE

  • China HANGZHOU THINK CHEMICAL CO. [Manufacturer]
  • Tel: +86-571-81956191/ +86-571-81956192
  • Fax: +86-571-81956190
  • Address: 425 MOGAN HILL ROAD ,
    HANGZHOU, 310011 CHINA null,nullChina
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123524-52-7 Azelnidipine

  • China Shanghai Xunxin Chemical Co., Ltd [Manufacturers]
  • Tel: +86-(21)-38218795
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  • Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315, Shanghai,ShanghaiChina
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  • China Watson International Ltd. null
  • Tel: +86-(512)-55117610
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  • Address: Room 1209, Asia Pacific Plaza, Huaqiao International Business Park, Kunshan, Jiangsu 215332, null,nullChina
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123524-52-7 Azelnidipine

  • China Laiwu Hehui Chemical Co.,Ltd. null
  • Tel: +86-(531)-88772589
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  • Address: Huashan Rd., Jinan City, Shandong 250000, null,nullChina
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  • China Boronsyn Co.,Ltd [Manufacturer]
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  • Address: 1213 JunMin Road,Pudong,China null,nullChina
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123524-52-7 Azelnidipine

  • Azelnidipine
  • Germany Paragos [Manufacturer]
  • Tel: +49 69 41 09 21 91
  • Fax: +49 69 42 69 45 85
  • Address: Alt Fechenheim 3460386 Frankfurt/MainGERMANY Frankfurt/Main,nullGermany
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References of 3-O-(1-benzhydrylazetidin-3-yl) 5-O-propan-2-yl
2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Title: Azelnidipine
CAS Registry Number: 123524-52-7
CAS Name: 2-Amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-(1-methylethyl) ester
Synonyms: (±)-3-(1-diphenylmethylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
Manufacturers' Codes: CS-905; RS-9054
Trademarks: Calblock (Sankyo)
Molecular Formula: C33H34N4O6
Molecular Weight: 582.65
Percent Composition: C 68.03%, H 5.88%, N 9.62%, O 16.48%
Literature References: Dihydropyridine L-type calcium channel blocker. Prepn: H. Koike et al., EP 266922; eidem, US 4772596 (both 1988 to Sankyo); T. Kobayashi et al., Chem. Pharm. Bull. 43, 797 (1995). Clinical evaluation in hypertension: M. Arita et al., J. Cardiovasc. Pharmacol. 33, 186 (1999). Review of pharmacology: Y. Yagil, A. Lustig, Cardiovasc. Drug Rev. 13, 137-148 (1995); of development, pharmacokinetics, safety, and clinical experience: H. Koike et al., Annu. Rep. Sankyo Res. Lab. 54, 1-64 (2002); of pharmacology and clinical experience: K. Wellington, L. J. Scott, Drugs 63, 2613-2621 (2003).
Properties: Pale yellow to yellow crystalline powder, mp 122-123°. Insol in water. pKa 7.89. LD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally (Koike).
Melting point: mp 122-123°
pKa: pKa 7.89
Toxicity data: LD50 in female, male mice, female, male rats (mg/kg): 785, 979, 1267, 1971 orally
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive; Dihydropyridine Derivatives.