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CAS No 123948-87-8 , Topotecan

  • Name: Topotecan
  • Synonyms: Hycamptin; Topotecan lactone; Hycamptamine; Topotecane [INN-French];Topotecan; Hycamtamine; Topotecanum; Topotecanum [INN-Latin];Hycamtin;
  • CAS Registry Number:
  • Transport: UN 3286 3/PG 2
  • Melting Point: −114 °C(lit.)
  • Flash Point: 427.3°C
  • Boiling Point: >100 °C(lit.)
  • Density: 1.49g/cm3
  • Refractive index: 1.733
  • Safety Statements: S26;S45;S36/37/39;S37/39;
  • Hazard Symbols: T,C,F,Xi
  • Flash Point: 427.3°C
  • EINECS: 231-595-7
  • Molecular Weight: 421.44582
  • InchiKey: UCFGDBYHRUNTLO-QHCPKHFHSA-N
  • InChI: InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-
    22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,
    1-3H3/t23-/m0/s1
  • Risk Statements: 36/37/38-67-35-20-11-34
  • Molecular Formula: C23H23N3O5
  • Molecular Structure:CAS No:123948-87-8 Topotecan

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References of Topotecan
Title: Topotecan
CAS Registry Number: 123948-87-8
CAS Name: (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3￠,4￠:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
Synonyms: 9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin; hycamptamine
Manufacturers' Codes: SKF-104864
Molecular Formula: C23H23N3O5
Molecular Weight: 421.45
Percent Composition: C 65.55%, H 5.50%, N 9.97%, O 18.98%
Literature References: DNA topoisomerase I inhibitor; semisynthetic analog of camptothecin, q.v. Prepn: J. C. Boehm et al., EP 321122; eidem, US 5004758 (1989, 1991 both to SmithKline Beecham); W. D. Kingsbury et al., J. Med. Chem. 34, 98 (1991). HPLC determn in plasma: J. H. Beijnen et al., J. Pharm. Biomed. Anal. 8, 789 (1990). Clinical pharmacology: E. K. Rowinsky et al., J. Clin. Oncol. 10, 647 (1992); and pharmacokinetics: L. J. C. van Warmerdam et al., Cancer Chemother. Pharmacol. 38, 254 (1996). Clinical evaluation in ovarian cancer: A. P. Kudelka et al., J. Clin. Oncol. 14, 1552 (1996); in small cell lung cancer: J. H. Schiller et al., ibid. 2345. Review of clinical toxicity: K. Seiter, Expert Opin. Drug Safety 4, 45-53 (2005).
 
Derivative Type: Hydrochloride
CAS Registry Number: 119413-54-6
Manufacturers' Codes: NSC-609669; SKF-104864A
Trademarks: Hycamtin (GSK)
Molecular Formula: C23H23N3O5.HCl
Molecular Weight: 457.91
Percent Composition: C 60.33%, H 5.28%, N 9.18%, O 17.47%, Cl 7.74%
Properties: Light yellow to greenish powder, mp 213-218° (dec). Soluble in water up to 1 mg/ml.
Melting point: mp 213-218° (dec)
 
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Alkaloids/Natural Products; Camptothecin Derivatives; Topoisomerase I Inhibitor.