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CAS No 127-07-1 , hydroxyurea

  • Name: hydroxyurea
  • Synonyms: Hydrea; Hydura; Droxia; Biosupressin; Oxyurea; N-Hydroxyurea; Litalir; Onco-carbide;Hydroxycarbamide;hydroxyurea;
  • CAS Registry Number:
  • Transport: HAZARD
  • Melting Point: 142-146 ºC
  • Flash Point: °C
  • Boiling Point: °Cat760mmHg
  • Density: 1.457g/cm3
  • Refractive index: 1.543
  • Safety Statements: R46;R61
  • Hazard Symbols: T: Toxic;
  • Flash Point: °C
  • EINECS: 204-821-7
  • Molecular Weight: 76.05466
  • InchiKey: VSNHCAURESNICA-UHFFFAOYSA-N
  • InChI: InChI=1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)
  • Risk Statements: S45;S53
  • Molecular Formula: CH4N2O2
  • Molecular Structure:CAS No:127-07-1 hydroxyurea

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References of hydroxyurea
Title: Hydroxyurea
CAS Registry Number: 127-07-1
Synonyms: Hydroxycarbamide
Trademarks: Droxia (BMS); Hydrea (BMS); Litalir (BMS)
Molecular Formula: CH4N2O2
Molecular Weight: 76.05
Percent Composition: C 15.79%, H 5.30%, N 36.84%, O 42.08%
Line Formula: H2NCONHOH
Literature References: Ribonuleotide reductase inhibitor; blocks DNA synthesis and repair. Induces fetal hemoglobin production in patients with sickle cell anemia. Prepn: W. F. C. Dressler, R. Stein, Ann. 150, 242 (1869). Alternate route: P. J. Graham, US 2705727 (1955 to Du Pont). Symposium on mechanism of action and clinical experience in cancer: Semin. Oncol. 19, Suppl. 9, 1-116 (1992). Clinical trials in sickle cell crises in adults: S. Charache et al., N. Engl. J. Med. 332, 1317 (1995); in children: T. R. Kinney et al., Blood 94, 1550 (1999). Review of clinical pharmacokinetics: P. R. Gwilt, W. G. Tracewell, Clin. Pharmacokinet. 34, 347-358 (1998); of pharmacology and potential therapeutic indications: P. Navarra, P. Preziosi, Crit. Rev. Oncol. Hematol. 29, 249-255 (1999). Clinical trial in essential thrombocythemia: C. N. Harrison et al., N. Engl. J. Med. 353, 33 (2005).
Properties: Needles from alc, mp 133-136°. Freely sol in water, hot alcohol.
Melting point: mp 133-136°
Therap-Cat: Antineoplastic; in treatment of sickle cell anemia.
Keywords: Antineoplastic.