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CAS No 127-69-5 , 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide Search by region : Germany

  • Name: 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
  • Synonyms: Sulphafurazole; Sulfafurazol; Gantrisin;Sulfafurazole;4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide; Sulfisoxazol; Sulfisoxasole; Sulfofurazole; Sulfaisoxazole;
  • CAS Registry Number:
  • Melting Point: 195 ºC
  • Flash Point: 245.4°C
  • Boiling Point: 482.2°Cat760mmHg
  • Density: 1.411g/cm3
  • Refractive index: 1.626
  • Water Solubility: <0.1 G/100 ML AT 22.5 ºC
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • Flash Point: 245.4°C
  • EINECS: 204-858-9
  • Molecular Weight: 267.30422
  • InchiKey: NHUHCSRWZMLRLA-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H13N3O3S/c1-7-8(2)13-17-11(7)14-18(15,
    16)10-5-3-9(12)4-6-10/h3-6,14H,12H2,1-2H3
  • Risk Statements: S26;S36
  • Molecular Formula: C11H13N3O3S
  • Molecular Structure:CAS No:127-69-5 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide

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127-69-5 SULFISOXAZOLE

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References of 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Title: Sulfisoxazole
CAS Registry Number: 127-69-5
CAS Name: 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide
Synonyms: N1-(3,4-dimethyl-5-isoxazolyl)sulfanilamide; 3,4-dimethyl-5-sulfanilamidoisoxazole; 5-(4-aminophenylsulfonamido)-3,4-dimethylisoxazole; 5-(p-aminobenzenesulfonamido)-3,4-dimethylisooxazole; sulfafurazole; sulphafurazole
Molecular Formula: C11H13N3O3S
Molecular Weight: 267.30
Percent Composition: C 49.43%, H 4.90%, N 15.72%, O 17.96%, S 12.00%
Literature References: Prepn: H. M. Wuest, M. Hoffer, US 2430094 (1947 to Hoffmann-La Roche). Toxicity study: Seki et al., Arzneim.-Forsch. 15, 1441 (1965). Comprehensive description: B. C. Rudy, B. Z. Senkowski, Anal. Profiles Drug Subs. 2, 487-506 (1973). HPLC determn in biological fluids: D. Jung, S. Oie, Clin. Chem. 26, 51 (1980). Clinical trial in otitis media: P. A. M. Bernard et al., Pediatrics 88, 215 (1991).
Properties: White to slightly yellowish crystalline powder. Bitter taste. mp 194°. pKa 5. Soly in water (25°): 0.13 mg/ml. Sol in alcohol. LD50 orally in mice: 6800 mg/kg (Seki).
Melting point: mp 194°
pKa: pKa 5
Toxicity data: LD50 orally in mice: 6800 mg/kg (Seki)
 
Derivative Type: Diethanolamine salt
CAS Registry Number: 4299-60-9
Synonyms: Sulfisoxazole diolamine
Molecular Formula: C11H13N3O3S.C4H11NO2
Molecular Weight: 372.44
Percent Composition: C 48.37%, H 6.50%, N 15.04%, O 21.48%, S 8.61%
Properties: White to off-white, odorless, crystalline powder. Sol in alcohol; freely sol in water. A 4% soln is about isotonic with tears.
 
Derivative Type: Acetyl sulfisoxazole
CAS Registry Number: 80-74-0
CAS Name: N-[(4-Aminophenyl)sulfonyl]-N-(3,4-dimethyl-5-isoxazolyl)acetamide
Synonyms: N1-monoacetyl sulfisoxazole
Trademarks: Gantrisin (Roche)
Molecular Formula: C13H15N3O4S
Molecular Weight: 309.34
Percent Composition: C 50.47%, H 4.89%, N 13.58%, O 20.69%, S 10.37%
Literature References: Prepn: M. Hoffer, US 2721200 (1955 to Hoffmann-La Roche). Should not be confused with N4-acetyl sulfisoxazole which is a metabolite.
Properties: Tasteless crystals, mp 193-194°. Soly (mg/ml): 0.07 in water; 4.93 in methanol; 5.7 in 95% ethanol; 0.94 in ether; 29.0 in chloroform.
Melting point: mp 193-194°
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.