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CAS No 12758-40-6 , 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid

  • Name: 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
  • Synonyms: Carboxyethylgermanium sesquioxide; 14C-Proxigermanium;3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid; 2-Carboxyethylgermasesquioxane; Ge 132;Propagermanium;
  • CAS Registry Number:
  • Safety Statements: Moderately toxic by intravenous route. Experimental reproductive effects. See also GERMANIUM COMPOUNDS.
  • EINECS: 235-800-0
  • Molecular Weight: 339.4194
  • InchiKey: XEABSBMNTNXEJM-UHFFFAOYSA-N
  • InChI: InChI=1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,
    10)(H,11,12)
  • Risk Statements: 36/37/38
  • Molecular Formula: C6H10Ge2O7
  • Molecular Structure:CAS No:12758-40-6 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid

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References of 3-[[2-carboxyethyl(oxo)germyl]oxy-oxogermyl]propanoic acid
Title: Propagermanium
CAS Registry Number: 12758-40-6
CAS Name: 3,3￠-(1,3-Dioxo-1,3-digermoxanediyl)bispropanioic acid
Synonyms: 2-(carboxyethyl)germanium sesquioxide; 3-oxygermylpropionic acid polymer; poly-trans-[(2-carboxyethyl)germasesquioxane]; proxigermanium; repagermanium
Manufacturers' Codes: GE-132; SK-818
Trademarks: Serocion
Molecular Formula: C6H10Ge2O7
Molecular Weight: 339.42
Percent Composition: C 21.23%, H 2.97%, Ge 42.80%, O 33.00%
Line Formula: (GeCH2CH2COOH)2O3
Literature References: Biologic response modifier. Polymeric organogermanium compound. Orginally synthesized at Asai Germanium Institute in 1967. Prepn and crystal structure: M. Tsutsui et al., J. Am. Chem. Soc. 98, 8287 (1976). Toxicology and clinical pharmacokinetics: K. Miyao et al., Curr. Chemother. Infect. Dis. 2, 1527 (1979). TLC quantitation: X. Peishan et al., J. Planar Chromatogr. Mod. TLC 3, 141 (1990). Electrochemical behavior and determn: K. Hasebe et al., Electroanalysis 6, 779 (1994). Antiviral activity: Y. Ishiwata et al., Arzneim.-Forsch. 44, 357 (1994). Review of biological activities and mechanism of antitumor action: R. R. Brutkiewicz, F. Suzuki, In Vivo 1, 189-204 (1987). Review: K. Miyao, N. Tanaka, Drugs Future 13, 441-453 (1988). Review of clinical use as an immunostimulant: H. Fukazawa et al., Head Neck 16, 30-38 (1994).
Properties: Colorless, monoclinic crystals or crystalline powder having no odour but a slightly acidic taste. mp 270° (dec). pKa 3.6. Sol in water at 1.09% at 20°. Insol or very slightly sol in almost all organic solvents. Very sol in water under alkaline conditions; >10% at pH 7.4. Aq solns exhibit acid reactions. Stable at pH 2-12, especially at pH 7.4 especially where decomposition does not occur at 110° for 5 min. LD50 i.p. in mice: 2.8 g/kg (Brutkiewicz).
Melting point: mp 270° (dec)
pKa: pKa 3.6
Toxicity data: LD50 i.p. in mice: 2.8 g/kg (Brutkiewicz)
Therap-Cat: Antineoplastic; immunostimulant.
Keywords: Antineoplastic; Immunomodulators; Immunomodulator.