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CAS No 128270-60-0 , Bivalirudin

  • Name: Bivalirudin
  • Synonyms: BG-8967; 128270-60-0; bivalirudine; Hirulog; Hirulog-1; bivalirudina;Bivalirudin; CHEBI:59173; bivalirudinum;Angiomax;
  • CAS Registry Number:
  • Density: 1.52 g/cm3
  • Refractive index: 1.675
  • Molecular Weight: 2180.28532
  • InchiKey: OIRCOABEOLEUMC-GEJPAHFPSA-N
  • InChI: InChI=1S/C98H138N24O33/c1-5-52(4)82(96(153)122-39-15-23-70(122)92(149)
    114-60(30-34-79(134)135)85(142)111-59(29-33-78(132)133)86(143)116-64(43-
    55-24-26-56(123)27-25-55)89(146)118-67(97(154)155)40-51(2)3)119-87(144)
    61(31-35-80(136)137)112-84(141)58(28-32-77(130)131)113-88(145)63(42-54-
    18-10-7-11-19-54)117-90(147)66(45-81(138)139)110-76(129)50-107-83(140)65
    (44-71(100)124)109-75(128)49-106-73(126)47-104-72(125)46-105-74(127)48-
    108-91(148)68-21-13-38-121(68)95(152)62(20-12-36-103-98(101)102)115-93
    (150)69-22-14-37-120(69)94(151)57(99)41-53-16-8-6-9-17-53/h6-11,16-19,
    24-27,51-52,57-70,82,123H,5,12-15,20-23,28-50,99H2,1-4H3,(H2,100,124)(H,
    104,125)(H,105,127)(H,106,126)(H,107,140)(H,108,148)(H,109,128)(H,110,
    129)(H,111,142)(H,112,141)(H,113,145)(H,114,149)(H,115,150)(H,116,
    143)(H,117,147)(H,118,146)(H,119,144)(H,130,131)(H,132,133)(H,134,
    135)(H,136,137)(H,138,139)(H,154,155)(H4,101,102,103)/t52-,57+,58-,59-,
    60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82-/m0/s1
  • Molecular Formula: C98H138N24O33
  • Molecular Structure:CAS No:128270-60-0 Bivalirudin

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128270-60-0 Bivalirudin

  • Bivalirudin Bivalirudin Trifluoroacetate
  • United States ChemPep, Inc. [Manufacturer]
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  • Address: 7225 NW 68th St, Suite 5 33166 Miami, FLUNITED STATES 33166 Miami, FL,nullUnited States
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128270-60-0 BIVALIRUDIN

  • China TCS INDUSTRY LTD [Manufacturer]
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128270-60-0 Bivalirudin

  • China Hallochem Pharma Co.,Ltd [Manufacturers]
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128270-60-0 Bivalirudin

  • China Shanghai TASH&Peptide-Bio.Co.Ltd [Manufacturers]
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128270-60-0 Bivalirudin

  • Bivalirudin
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128270-60-0 Bivalirudin Trifluoroacetate

  • Bivalirudin belongs to the anticoagulant class and acts as a direct thrombin inhibitor. Fields of application For use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty(PTCA), percutaneous c...
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128270-60-0 Bivalirudin

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128270-60-0 Bivalirudin

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References of Bivalirudin
Title: Bivalirudin
CAS Registry Number: 128270-60-0
Synonyms: Hirulog-1; hirulog-8
Manufacturers' Codes: BG-8967
Trademarks: Angiomax (Medicines Co.); Angiox (Nycomed); Hirulog (Medicines Co.)
Molecular Formula: C98H138N24O33
Molecular Weight: 2180.29
Percent Composition: C 53.99%, H 6.38%, N 15.42%, O 24.22%
Literature References: Synthetic peptide of 20 amino acids; member of a novel class of bivalent direct thrombin inhibitors. Characterized by an anion binding exosite (ABE) derived from hirudin, q.v., linked to a thrombin catalytic site inhibitor moiety by tetraglycine. Prepn and structure activity study: J. M. Maraganore et al., WO 9102750; eidem, US 5196404 (1991, 1993 both to Biogen); eidem, Biochemistry 29, 7095 (1990). Determn in plasma and whole blood: T. J. Reid, B. M. Alving, Thromb. Haemostasis 70, 608 (1993). Clinical pharmacology: I. Fox et al., ibid. 69, 157 (1993). Clinical study in myocardial infarction: P. Théroux et al., Circulation 91, 2132 (1995); during coronary angioplasty: J. A. Bittl et al., N. Engl. J. Med. 333, 764 (1995). Clinical trial with provisional glycoprotein IIb/IIIa inhibition during percutaneous coronary intervention: A. M. Lincoff et al., J. Am. Med. Assoc. 289, 853 (2003). Review of pharmacology and clinical development: T. D. Gladwell, Clin. Ther. 24, 38-58 (2002); of clinical experience in acute coronary syndromes: J. S. Kalus, M. F. Caron, Expert Opin. Invest. Drugs 13, 465-477 (2004).
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Anticoagulant.