Title: Fulvestrant
CAS Registry Number: 129453-61-8
CAS Name: (7a,17b)-7-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
Manufacturers' Codes: ICI-182780
Trademarks: Faslodex (AstraZeneca)
Molecular Formula: C32H47F5O3S
Molecular Weight: 606.77
Percent Composition: C 63.34%, H 7.81%, F 15.66%, O 7.91%, S 5.28%
Literature References: Novel steroidal estrogen antagonist reported to lack any partial agonist activity. Prepn: J. Bowler, B. S. Tait,
EP 138504;
eidem, US 4659516 (1985, 1987 both to ICI). Pharmacology: A. E. Wakeling
et al., Cancer Res. 51, 3867 (1991). Clinical pharmacokinetics: A. Howell
et al., Br. J. Cancer 74, 300 (1996). Clinical evaluation in breast cancer vs tamoxifen: J. F. Robertson
et al., Cancer Res. 61, 6739 (2001). Clinical trial in advanced breast cancer: J. N. Ingle
et al., J. Clin. Oncol. 24, 1052 (2006). Review of mechanism of action and clinical evaluation:
idem, Br. J. Cancer 85, Suppl. 2, 11-14 (2001); A. Howell,
Crit. Rev. Oncol. Hematol. 57, 265-273 (2006); of tolerability profile: I. Vergote, P. Abram,
Ann. Oncol. 17, 200-204 (2006).
Therap-Cat: Antineoplastic (hormonal).
Keywords: Antineoplastic (Hormonal); Antiestrogens.
![CAS No:129453-61-8 (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,<br />5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,<br />17-decahydrocyclopenta[a]phenanthrene-3,17-diol](/structure/cas-129/129453-61-8.png)
