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CAS No 130209-82-4 , Latanoprost

  • Name: Latanoprost
  • Synonyms: (1r-(1-alpha(z),2-beta(r*),3-alpha,5-alpha))--methylethyleste; 9ALPHA, 11ALPHA, 15S-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROS-5Z-EN-1-OIC ACID, ISOPROPYL ESTER; propan-2-yl.7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate;Propan-2-yl 7-[3,5-dihydroxy-2-(3-hydroxy-5-phenyl-pentyl)-cyclopentyl]hept-5-enoate; 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoicaci1; ISOPROPYL (5Z, 9A,11A,15R)-9,11,15-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OATE; 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER; 9ALPHA,11ALPHA,15R-TRIHYDROXY-17-PHENYL-18,19,20-TRINOR-PROST-5Z-EN-1-OIC ACID, ISOPROPYL ESTER;Latanoprost;XALATAN;
  • CAS Registry Number:
  • Density: 1.093 g/cm3
  • Refractive index: 1.537
  • Water Solubility: DMSO: freely soluble
  • Safety Statements: A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.
  • Molecular Weight: 432.60
  • InChI: InChI=1/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3+/t21-,22+,23+,24-,25+/m0/s1
  • Molecular Formula: C26H40O5
  • Molecular Structure:CAS No:130209-82-4 Latanoprost

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References of Latanoprost
Title: Latanoprost
CAS Registry Number: 130209-82-4
CAS Name: (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoic acid 1-methylethyl ester
Synonyms: isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]-5-heptenoate; 13,14-dihydro-17-phenyl-18,19,20-trinor-PGF2a-isopropyl ester
Manufacturers' Codes: PhXA-41
Trademarks: Xalatan (Pharmacia & Upjohn)
Molecular Formula: C26H40O5
Molecular Weight: 432.59
Percent Composition: C 72.19%, H 9.32%, O 18.49%
Literature References: Prostaglandin analog; prodrug of active acid metabolite. Prepd (not claimed): J. Ivanics et al., WO 9300329 (1993 to Kabi Pharmacia; Chinoin). Prepn: B. Resul et al., J. Med. Chem. 36, 243, 2242 (corr.) (1993). Clinical pharmacology: C. B. Toris et al., Ophthalmology 100, 1297 (1993). Clinical evaluation in glaucoma: P. Rácz et al., Arch. Ophthalmol. 111, 657 (1993); as single therapy and in combination with timolol, q.v.: A. H. Rulo et al., Br. J. Ophthalmol. 78, 899 (1994). Review of preclinical pharmacology: J. Stjernschantz et al., Adv. Prostaglandin Thromboxane Leukotriene Res. 23, 513-518 (1995).
Properties: Colorless oil. [a]D20 +31.57° (c = 0.91 in acetonitrile). Very sol in acetonitrile; freely sol in acetone, ethanol, ethyl acetate, isopropanol, methanol, octanol. Practically insol in water.
Optical Rotation: [a]D20 +31.57° (c = 0.91 in acetonitrile)
Therap-Cat: Antiglaucoma.
Keywords: Antiglaucoma; Prostaglandin/Prostaglandin Analog.