Home > Name List By 2 > 2-(dimethylamino)ethyl 4-(butylamino)benzoate Switzerland

CAS No 136-47-0 , 2-(dimethylamino)ethyl 4-(butylamino)benzoate Search by region : Switzerland

  • Name: 2-(dimethylamino)ethyl 4-(butylamino)benzoate
  • Synonyms: Pantocaine; Intercaine; Anethain; Anethaine;hydrochloride; Butethanol;Tetracaine hydrochloride; Curtacain;2-(dimethylamino)ethyl 4-(butylamino)benzoate; Butylocaine; 136-47-0; Tetracaine HCl;
  • CAS Registry Number:
  • Transport: UN 2811
  • Melting Point: 149ºC
  • Flash Point: 189.3 ºC
  • Boiling Point: 389.4 ºC at 760 mmHg
  • Density: g/cm3
  • Water Solubility: freely soluble in water, soluble in alcohol and practically insoluble in ether.
  • Safety Statements: R25;R36;R43
  • Hazard Symbols: T: Toxic;
  • Flash Point: 189.3 ºC
  • EINECS: 205-248-5
  • Molecular Weight: 300.8242
  • InchiKey: PPWHTZKZQNXVAE-UHFFFAOYSA-N
  • InChI: InChI=1S/C15H24N2O2.ClH/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17
    (2)3;/h6-9,16H,4-5,10-12H2,1-3H3;1H
  • Risk Statements: S26;S36/37;S45
  • Molecular Formula: C15H25ClN2O2
  • Molecular Structure:CAS No:136-47-0 2-(dimethylamino)ethyl 4-(butylamino)benzoate

Related products

Select to

136-47-0 Tetracaine hydrochloride

  • Tetracaine hydrochloride, 99.8%
  • Switzerland BIOTREND Chemicals AG [Manufacturer]
  • Tel: +41 44 805 76 76
  • Fax: +41 44 805 76 77
  • Address: BIOTREND Chemicals AG
    Unterdorfstr. 21b
    CH-8602 Wangen/Zuerich
    Switzerland null,nullSwitzerland
Contact Supplier

Select to

1/1
References of 2-(dimethylamino)ethyl 4-(butylamino)benzoate
Title: Tetracaine Hydrochloride
CAS Registry Number: 136-47-0
CAS Name: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester monohydrochloride
Synonyms: p-butylaminobenzoyl-2-dimethylaminoethanol hydrochloride; 2-dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; dicain; amethocaine hydrochloride
Trademarks: Anethaine (Glaxo); Decicain (Winthrop); Pantocaine (Hoechst); Pontocaine Hydrochloride (Sanofi Winthrop); Tonexol (Pharmaton)
Molecular Formula: C15H25ClN2O2
Molecular Weight: 300.82
Percent Composition: C 59.89%, H 8.38%, Cl 11.79%, N 9.31%, O 10.64%
Literature References: Prepn: US 1889645 (1932); GB 815144 (1959 to Abbott). Prepn of pharmaceutical dosage forms: Shupe, US 3272700 (1966 to Sterling Drug). Mechanism of action studies: Y.-W. Leung et al., J. Infect. Dis. 136, 679 (1977). Toxicity study: Dawes, Br. J. Pharmacol. Chemother. 1, 90 (1946). Acute toxicity: B. A. Bopp et al., J. Pharm. Sci. 67, 882 (1978). Comprehensive description: M. Riaz, Anal. Profiles Drug Subs. 18, 379-411 (1989).
Properties: Faintly bitter crystals producing transient numbness of the tongue. mp 147-150°. pKa 8.39. uv max (water): 225, 310 nm (e 14108, 26352); (0.1N H2SO4): 229, 281, 312 nm (E1%1cm 509, 55, 76); (methanol): 226, 310 nm (e 7586, 29512); (chloroform): 308 nm (e 27542). Sol at 20° in 7.5 parts water, 40 parts alcohol; 30 parts chloroform. Practically insol in ether, benzene, acetone. The aq soln is neutral to litmus. Aq solns are stable and may be sterilized by brief boiling. LD50 i.p. in mice: 70 mg/kg (Dawes); also reported as LD50 in female mice (mg/kg): 13 i.v.; 35 s.c. (Bopp).
Melting point: mp 147-150°
pKa: pKa 8.39
Absorption maximum: uv max (water): 225, 310 nm (e 14108, 26352); (0.1N H2SO4): 229, 281, 312 nm (E1%1cm 509, 55, 76); (methanol): 226, 310 nm (e 7586, 29512); (chloroform): 308 nm (e 27542)
Toxicity data: LD50 i.p. in mice: 70 mg/kg (Dawes); also reported as LD50 in female mice (mg/kg): 13 i.v.; 35 s.c. (Bopp)
Therap-Cat: Anesthetic (local).
Therap-Cat-Vet: Anesthetic (topical).
Keywords: Anesthetic (Local).