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CAS No 13669-70-0 , 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine Search by region : France

  • Name: 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine
  • Synonyms: Sinalgico; Nefopamum [INN-Latin]; 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine; Nefopam [INN:BAN]; 13669-70-0;5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine;Fenazoxine;
  • CAS Registry Number:
  • Flash Point: 109°C
  • Boiling Point: 369.5°C at 760 mmHg
  • Density: 1.064g/cm3
  • Refractive index: 1.563
  • Safety Statements: Poison by ingestion, intravenous, intraperitoneal, and intramuscular routes. Human systemic effects by ingestion: hallucinations, distorted perceptions, excitement, motor activity changes, increased pulse rate without blood pressure fall and heart rate changes. When heated to decomposition it emits toxic fumes of NOx.
  • Flash Point: 109°C
  • EINECS: 237-148-2
  • Molecular Weight: 253.33886
  • InchiKey: RGPDEAGGEXEMMM-UHFFFAOYSA-N
  • InChI: InChI=1S/C17H19NO/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)
    13-18/h2-10,17H,11-13H2,1H3
  • Molecular Formula: C17H19NO
  • Molecular Structure:CAS No:13669-70-0 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine

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13669-70-0 NEFOPAM

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References of 5-methyl-1-phenyl-1,3,4,6-tetrahydro-2,5-benzoxazocine
Title: Nefopam
CAS Registry Number: 13669-70-0
CAS Name: 3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine
Synonyms: 5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine
Molecular Formula: C17H19NO
Molecular Weight: 253.34
Percent Composition: C 80.60%, H 7.56%, N 5.53%, O 6.32%
Literature References: A cyclized analog of orphenadrine and diphenhydramine, q.q.v.; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Prepn: NL 6606390 (1966 to Rexall); M. W. Klohs et al., US 3830803 (1974 to Riker). Pharmacology: Bassett et al., Br. J. Pharmacol. 37, 69 (1969); Klohs et al., Arzneim.-Forsch. 22, 132 (1972). Review of pharmacology and therapeutic efficacy: R. C. Heel et al., Drugs 19, 249-267 (1980).
 
Derivative Type: Hydrochloride
CAS Registry Number: 23327-57-3
Synonyms: Fenazoxine
Manufacturers' Codes: R-738
Trademarks: Acupan (3M); Ajan (3M)
Molecular Formula: C17H19NO.HCl
Molecular Weight: 289.80
Percent Composition: C 70.46%, H 6.96%, N 4.83%, O 5.52%, Cl 12.23%
Properties: mp 238-242°. LD50 in mice, rats (mg/kg): 119, 178 orally; 44.5, 28 i.v. (Baltes).
Melting point: mp 238-242°
Toxicity data: LD50 in mice, rats (mg/kg): 119, 178 orally; 44.5, 28 i.v. (Baltes)
 
Therap-Cat: Analgesic; antidepressant.
Keywords: Analgesic (Non-Narcotic); Antidepressant; Bicyclics.