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CAS No 137-58-6 , 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Search by region : India

  • Name: 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
  • Synonyms: Leostesin;Xylocaine;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide; Lidoderm; Lignocaine; Gravocain; Maricaine; Esracaine; Anestacon; Alphacaine;
  • CAS Registry Number:
  • Transport: 25kgs
  • Melting Point: 66-69 ºC
  • Flash Point: 166°C
  • Boiling Point: 350.8°Cat760mmHg
  • Density: 1.026g/cm3
  • Safety Statements: R22
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 166°C
  • EINECS: 205-302-8
  • Molecular Weight: 234.33728
  • InchiKey: NNJVILVZKWQKPM-UHFFFAOYSA-N
  • InChI: InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,
    5-6,10H2,1-4H3,(H,15,17)
  • Risk Statements: S22;S26;S36
  • Molecular Formula: C14H22N2O
  • Molecular Structure:CAS No:137-58-6 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

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137-58-6 lidocaine

  • IUPAC NAME-2-(diethylamino)- N-(2,6-dimethylphenyl)acetamide MOLECULAR FORMULA-C14H22N2O MOLAR MASS-234.34 g/mol Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local a...
  • India Swapnroop Drugs & Pharmaceuticals [Manufacturer, Trading Company, Distributor/Wholesaler]
  • Tel: 91-240-6641875
  • Fax: 91-240-6641870
  • Address: Plot No: 04, Mayur Park Road, Harsool Aurangabad,MaharashtraIndia

137-58-6 LIDOCAINE-D6

  • India VARDA Biotech (P) Ltd. [Manufacturer]
  • Tel: +91-22-6693 5686 / 2673 0141 / 2673 4258
  • Fax: +91-22-6693 5687
  • Address: 110 & 111, Kartik Complex
    New link Road, Andheri-(W)
    Mumbai-400053, INDIA. null,nullIndia
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137-58-6 LIDOCAINE

  • India JAI RADHE SALES null
  • Fax: 0091-79-26569884
  • Address: 309/310 HARIKRUPA TOWER,NR.OLD SHARDA MANDIR CHAR RASTA,ELLISBRIDGE ,AHMEDABAD,GUJRAT , INDIA. null,nullIndia
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137-58-6 Lidocaine Base

  • India Shreeji Pharma International [Manufacturers]
  • Tel: +91-265-3019110
  • Fax: +91-265-2465036
  • Address: FF/10, Narsinghdham Complex, Sangam Chararasta, Harni Road, Vadodara, Gujarat 390018, Vadodara,GujaratIndia
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137-58-6 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide

  • India Ibis Chemie International [Manufacturers]
  • Tel: +91-22-22001993
  • Fax: +91-22-22088450
  • Address: 211 Dalamal Chambers,New Marine Lines,Mumbai 400020.India Mumbai,nullIndia
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137-58-6 Lidocaine Base

  • India Ions Pharma null
  • Tel: +91-(22)-25006213
  • Fax: +91-(22)-66756811
  • Address: A-106/107. Kanara Business Centre (KBC), Near Laxmi Nagar. Ghatkopar (E), Mumbai, Maharashtra 400086, null,nullIndia
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137-58-6 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide

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137-58-6 Lidocaine Base

  • India Steamline Industries Ltd. null
  • Tel: +91-(22)-40999700, 9833720865
  • Fax: +91-(22)-40999777
  • Address: 901/904 Jagdamba Commercial Complex A/2, Near Movitime Theatre, Link Road, Malad (W), Mumbai, Maharashtra 400064, null,nullIndia
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137-58-6 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide

  • India Mesha Pharma (P). Limited [Manufacturers]
  • Tel: +91 - 22 - 22431085
  • Address: 1/1, Mulchand Mansion 20/30, S.G.Marg,Mumbai : 400 002.Maharashtra Mumbai,MaharashtraIndia
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137-58-6 2-(Diethylamino)-N-(2,6-dimethylphenyl)-acetamide

  • India DOSHIL [Manufacturers]
  • Tel: +91 22 66974356, 57, 58
  • Fax: +91 22 66974359
  • Address: Laxmi Plaza Bldg. No:9 3 rd floor, Office No:319 Laxmi Ind. Est, New Link Road, Andheri (W) Mumbai - 400 053 INDIA. null,nullIndia
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References of 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
Title: Lidocaine
CAS Registry Number: 137-58-6
CAS Name: 2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide
Synonyms: 2-diethylamino-2¢,6¢-acetoxylidide; w-diethylamino-2,6-dimethylacetanilide; lignocaine
Trademarks: Cuivasil (IDC); Lidoderm (Hind); LidoPosterine (Kade); Vagisil (Combe)
Molecular Formula: C14H22N2O
Molecular Weight: 234.34
Percent Composition: C 71.75%, H 9.46%, N 11.95%, O 6.83%
Literature References: Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. Prepn: N. M. L?fgren, B. J. Lundqvist, US 2441498 (1948 to Astra); A. D. H. Self, A. P. T. Easson, GB 706409 (1954 to May & Baker); I. P. S. Hardie, E. S. Stern, GB 758224 (1956 to J. F. Macfarlane & Co.); Zhuravlev, Nikolaev, Zh. Obshch. Khim. 30, 1155 (1960). Toxicity studies: E. R. Smith, B. R. Duce, J. Pharmacol. Exp. Ther. 179, 580 (1971); G. H. Kronberg et al., J. Med. Chem. 16, 739 (1973). Review of pharmacokinetics: N. L. Benowitz, W. Meister, Clin. Pharmacokinet. 3, 177 (1978). Review of action as local anesthetic: L?fgren, Studies on Local Anesthetics: Xylocaine, A New Synthetic Drug (Hoeggstroms, Stockholm, 1948); Cooper, Pharm. J. 171, 68 (1953). Reviews of anti-arrhythmic agents: J. L. Anderson et al., Drugs 15, 271 (1978); L. H. Opie, Lancet 1, 861 (1980); E. Carmeliet, Ann. N.Y. Acad. Sci. 427, 1 (1984). Comprehensive description: K. Groningsson et al., Anal. Profiles Drug Subs. 14, 207-243 (1985); M. F. Powell, ibid. 15, 761-779 (1986). Review of use in treatment of postherpetic neuralgia: P. S. Davies, B. S. Galer, Drugs 64, 937-947 (2004).
Properties: Needles from benzene or alcohol, mp 68-69°. bp4 180-182°; bp2 159-160°. Insol in water. Sol in alcohol, ether, benzene, chloroform, oils. Partition coefficient (octanol/water, pH 7.4): 43.
Melting point: mp 68-69°
Boiling point: bp4 180-182°; bp2 159-160°
Log P: Partition coefficient (octanol/water, pH 7.4): 43
 
Derivative Type: Hydrochloride
CAS Registry Number: 73-78-9; 6108-05-0 (monohydrate)
Trademarks: Basicaina (Galenica); Batixim (So.Se.); Dynexan (Kreussler); Heweneural (Hevert); Licain (DeltaSelect); Lidesthesin (Ritsert); Lidofast (Angelini); Lidoject (Hexal); Lidrian (Baxter); Odontalg (Giovanardi); Sedagul (Wild); Xylocaine (AstraZeneca); Xylocard (AstraZeneca); Xylocitin (Jenapharm); Xyloneural (Strathmann)
Molecular Formula: C14H22N2O.HCl
Molecular Weight: 270.80
Percent Composition: C 62.09%, H 8.56%, N 10.34%, O 5.91%, Cl 13.09%
Properties: Crystals, mp 127-129°; monohydrate, mp 77-78°. Very sol in water, alcohol; sol in chloroform. Insol in ether. pH of 0.5% aq soln: 4.0-5.5. LD50 in mice (mg/kg): 292 orally (Smith, Duce); 105 i.p.; 19.5 i.v. (Kronberg).
Melting point: mp 127-129°; mp 77-78°
Toxicity data: LD50 in mice (mg/kg): 292 orally (Smith, Duce); 105 i.p.; 19.5 i.v. (Kronberg)
 
Therap-Cat: Anesthetic (local); antiarrhythmic (class IB).
Therap-Cat-Vet: Anesthetic (local).
Keywords: Anesthetic (Local); Antiarrhythmic.