Home > Name List By n > N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl] methanesulfonamide

CAS No 141626-36-0 , N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]
methanesulfonamide

  • Name: N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]
    methanesulfonamide
  • Synonyms: Dronedarone (INN); Dronedarone [INN]; SR 33589B; AC1L4LKA; CHEBI:50659; 141626-36-0;Multaq; UNII-JQZ1L091Y2; SR 33589;N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]
    methanesulfonamide;
  • CAS Registry Number:
  • Density: 1.143 g/cm3
  • Refractive index: 1.563
  • Molecular Weight: 556.75646
  • InchiKey: ZQTNQVWKHCQYLQ-UHFFFAOYSA-N
  • InChI: InChI=1S/C31H44N2O5S/c1-5-8-12-29-30(27-23-25(32-39(4,
    35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-
    6-2)20-10-7-3/h13-18,23,32H,5-12,19-22H2,1-4H3
  • Molecular Formula: C31H44N2O5S
  • Molecular Structure:CAS No:141626-36-0 N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]<br />methanesulfonamide

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References of N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]
methanesulfonamide
Title: Dronedarone
CAS Registry Number: 141626-36-0
CAS Name: N-[2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide
Synonyms: N,N-dibutyl-3-[4-[(2-butyl-5-methylsulfonamido)benzofuran-3-ylcarbonyl]phenoxy]propylamine
Manufacturers' Codes: SR-33589
Molecular Formula: C31H44N2O5S
Molecular Weight: 556.76
Percent Composition: C 66.87%, H 7.97%, N 5.03%, O 14.37%, S 5.76%
Literature References: Noniodinated analog of amiodarone, q.v. Prepn: J. Gubin et al., EP 471609; eidem, US 5223510 (1992, 1993 both to Sanofi). Hemodynamic and antiadrenergic effects in dogs: L. Djandjighian et al., J. Cardiovasc. Pharmacol. 36, 376 (2000). Electrophysiological effects in canine heart: A. Varró et al., Br. J. Pharmacol. 133, 625 (2001). Clinical pharmacokinetics and interaction with metoprolol, q.v.: T. Damy et al., Fundam. Clin. Pharmacol. 18, 113 (2004). Clinical evaluation in atrial fibrillation: P. Touboul et al., Eur. Heart J. 24, 1481 (2003).
Properties: Crystals from hexane, mp 65.3°.
Melting point: mp 65.3°
 
Derivative Type: Hydrochloride
CAS Registry Number: 141625-93-6
Manufacturers' Codes: SR-33589B
Molecular Formula: C31H45ClN2O5S
Molecular Weight: 593.22
Percent Composition: C 62.76%, H 7.65%, Cl 5.98%, N 4.72%, O 13.49%, S 5.41%
Properties: Colorless solid from acetone, mp 143°.
Melting point: mp 143°
 
Therap-Cat: Antiarrhythmic (class III).
Keywords: Antiarrhythmic.