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CAS No 1435-55-8 , Hydroquinidine Search by region : Germany

  • Name: Hydroquinidine
  • Synonyms: Dihydroquinine; (5-Ethyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol;Hydroquinidine; (8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol;
  • CAS Registry Number:
  • Transport: 1544
  • Melting Point: 169-170 ºC
  • Density: 1.2 g/cm3
  • Refractive index: 1.626
  • Alpha: 226 º (C=2 IN ETOH)
  • Water Solubility: chloroform: 0.1 g/mL, clear
  • Safety Statements: R20/21/22
  • Hazard Symbols: Xn: Harmful;
  • EINECS: 215-862-5
  • Molecular Weight: 326.43
  • InChI: InChI=1/C20H26N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h4-6,8,11,13-14,19-20,23H,3,7,9-10,12H2,1-2H3/t13-,14+,19+,20+/m0/s1
  • Risk Statements: S36/37
  • Molecular Formula: C20H26N2O2
  • Molecular Structure:CAS No:1435-55-8 Hydroquinidine

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References of Hydroquinidine
Title: Hydroquinidine
CAS Registry Number: 1435-55-8
CAS Name: (9S)-10,11-Dihydro-6￠-methoxycinchonan-9-ol
Synonyms: dihydroquinidine; hydroconchinine
Molecular Formula: C20H26N2O2
Molecular Weight: 326.43
Percent Composition: C 73.59%, H 8.03%, N 8.58%, O 9.80%
Literature References: An alkaloid of cinchona, stereoisomeric with hydroquinine. Usually prepd by hydrogenation of quinidine: Heidelberger, Jacobs, J. Am. Chem. Soc. 41, 826 (1919). Conversion to dihydrocinchonine by removal of the methoxy group: King, J. Chem. Soc. 1946, 523. Manuf pat.: Gutzwiller, Uskokovic, DE 1933599 (1970 to Hoffmann-La Roche), C.A. 72, 90696v (1970). Pharmacology: Cosnier et al., Therapie 26, 97 (1971).
Properties: Plates from ether, needles from alcohol, mp 169°. [a]D20 +231° (c = 2.02 in alc); +299° (c = 0.82 in 0.1N H2SO4). Readily sol in hot alcohol; slightly sol in water and ether.
Melting point: mp 169°
Optical Rotation: [a]D20 +231° (c = 2.02 in alc); +299° (c = 0.82 in 0.1N H2SO4)
 
Derivative Type: Hydrochloride
CAS Registry Number: 1476-98-8
Trademarks: Serecor (Houd?
Molecular Formula: C20H26N2O2.HCl
Molecular Weight: 362.89
Percent Composition: C 66.19%, H 7.50%, N 7.72%, O 8.82%, Cl 9.77%
Properties: Rhombic plates, mp 273-274°. [a]D26 +184° (c = 1.3). Freely sol in methanol, chloroform; less readily in water or abs alcohol; difficultly sol in dry acetone.
Melting point: mp 273-274°
Optical Rotation: [a]D26 +184° (c = 1.3)
 
Therap-Cat: Antiarrhythmic.
Keywords: Antiarrhythmic.