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CAS No 147-85-3 , (2S)-pyrrolidine-2-carboxylic acid Search by region : Switzerland

  • Name: (2S)-pyrrolidine-2-carboxylic acid
  • Synonyms: proline;L-proline; 2-pyrrolidinecarboxylic acid; L-(-)-Proline; (S)-2-Pyrrolidinecarboxylic acid; 147-85-3; (-)-Proline; (-)-(S)-Proline;(2S)-pyrrolidine-2-carboxylic acid;
  • CAS Registry Number:
  • Melting Point: 228-233 ºC
  • Density: 1.35
  • Refractive index: -85 ° (C=4, H2O)
  • Alpha: -85.5 º (C=4, H2O)
  • Safety Statements: R36/37/38
  • Hazard Symbols: Xi: Irritant;
  • HS Code: 29339990
  • EINECS: 205-702-2
  • Molecular Weight: 115.13046
  • InchiKey: ONIBWKKTOPOVIA-BYPYZUCNSA-N
  • InChI: InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1
  • Risk Statements: S24/25
  • Molecular Formula: C5H9NO2
  • Molecular Structure:CAS No:147-85-3 (2S)-pyrrolidine-2-carboxylic acid

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147-85-3 08075 H-PRO-OH L-PROLINE

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147-85-3 L-Proline

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References of (2S)-pyrrolidine-2-carboxylic acid
Title: Proline
CAS Registry Number: 147-85-3
CAS Name: L-Proline
Synonyms: Pro; P; (S)-2-pyrrolidinecarboxylic acid
Molecular Formula: C5H9NO2
Molecular Weight: 115.13
Percent Composition: C 52.16%, H 7.88%, N 12.17%, O 27.79%
Literature References: Non-essential amino acid for human development. Only imino acid of the 20 amino acids commonly found in proteins. Shows cis-trans isomerism. First synthesized: R. Willst?tter, Ber. 33, 1160 (1900); prior to identification in casein: E. Fischer, Ber. 34, 454 (1901). Named in 1904 by Fischer. Early chemistry and biochemistry: Amino Acids and Proteins, D. M. Greenberg, Ed. (Charles C. Thomas, Springfield, IL, 1951) 950 pp., passim; J. P. Greenstein, M. Winitz, Chemistry of the Amino Acids vols 1-3 (John Wiley and Sons, Inc., New York, 1961) pp. 2178-2201, passim. Stereospecific synthesis: S. L. Titouani et al., Tetrahedron 36, 2961 (1980). HPLC determn: A. Carisano, J. Chromatogr. 318, 132 (1985). HPLC separation of cis-trans isomers of peptides: S. Friebe et al., ibid. A 661, 7 (1994). Review of biosynthesis and degradation: E. Adams, L. Frank, Annu. Rev. Biochem. 49, 1005-1061 (1980). Review of effects on protein structure and biological function: A. Yaron, F. Naider, Crit. Rev. Biochem. Mol. Biol. 28, 31-81 (1993); G. Vanhoof et al., FASEB J. 9, 736-744 (1995).
Properties: Flat needles from alcohol + ether, prisms from water, dec 220-222°. [a]D23.4 -85.0°; [a]D20 -52.6° (c = 0.57 in 0.50N HCl); [a]D20 -93.0° (c = 2.42 in 0.6N KOH). pI 6.30. pK1 1.99; pK2 10.60. Soly in 100 ml water: 127.4 g at 0°; 162.3 g at 25°; 206.7 g at 50°; 239 g at 65°. Sol in alcohol 1.55% at 35°. Insol in ether, butanol, isopropanol.
pKa: pK1 1.99; pK2 10.60
Optical Rotation: [a]D23.4 -85.0°; [a]D20 -52.6° (c = 0.57 in 0.50N HCl); [a]D20 -93.0° (c = 2.42 in 0.6N KOH)
 
Derivative Type: DL-Form
CAS Registry Number: 609-36-9
Properties: Monohydrate, crystals, mp 190° (when anhydr, dec 205°). Sol in water, alc; sparingly sol in acetone, chloroform, benzene; insol in ether.
Melting point: mp 190° (when anhydr, dec 205°)