Home > Name List By 4 > 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2- ylpyrimidin-4-yl]benzenesulfonamide China

CAS No 147536-97-8 , 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
ylpyrimidin-4-yl]benzenesulfonamide Search by region : China

  • Name: 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
    ylpyrimidin-4-yl]benzenesulfonamide
  • Synonyms: 147536-97-8; Ro-47-0203; CHEBI:51450;Tracleer; Ro 47-0203; Actelion; Bosentan hydrate; Bosentan (INN); bosentanum;4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
    ylpyrimidin-4-yl]benzenesulfonamide;
  • CAS Registry Number:
  • Melting Point: 195 ºC
  • Flash Point: 402.8 ºC
  • Boiling Point: 742.3 ºC at 760 mmHg
  • Density: 1.326 g/cm3
  • Refractive index: 1.607
  • Safety Statements: Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and SOx.
  • Flash Point: 402.8 ºC
  • Molecular Weight: 551.61406
  • InchiKey: GJPICJJJRGTNOD-UHFFFAOYSA-N
  • InChI: InChI=1S/C27H29N5O6S/c1-27(2,3)18-10-12-19(13-11-18)39(34,
    35)32-23-22(38-21-9-6-5-8-20(21)36-4)26(37-17-16-33)31-25(30-23)24-28-
    14-7-15-29-24/h5-15,33H,16-17H2,1-4H3,(H,30,31,32)
  • Molecular Formula: C27H29N5O6S
  • Molecular Structure:CAS No:147536-97-8 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-<br />ylpyrimidin-4-yl]benzenesulfonamide

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147536-97-8 Medicine ingredients Bosentan Hydrate, Bosentan from China supplier,Tracleer

  • Medicine ingredients Bosentan Hydrate, Bosentan from China supplier,Tracleer 1.Best price and good service 2.Offer Documents(GMP,DMF,COA) 3.Prompt shipment 4.New Drugs Medical uses Bosentan is a dual endothelin receptor antagonist used in the treatme...
  • Min. Order: 100
  • China Hunan Arshine Pharmaceutical Co. Ltd. [Trading Company]
  • Tel: 86-731-88960811
  • Address: RM 1105-1109, Lugu Enterprise Plaza, Wenxuan Road, Lugu High-tech Zone Changsha,HunanChina
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147536-97-8 147536-97-8

  • We are a manufacture, have lab and production base in china. Can provide you competitive price, with qualified compounds and convenience service. We can provide you custom synthesis and custom manufacturing,especially our catalogue product derivative...
  • China Shanghai MOF Chemical Tech Limited [Manufacturer]
  • Tel: 86-021-51386232
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  • Address: 4F No.BLDG18,88 Darwin Road,Pudong,Shanghai,P.R.China Pudong District,ShanghaiChina
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147536-97-8 BOSENTAN

  • China Taiyuan RHF CO., ltd. [Manufacturers]
  • Tel: 0351-7436719
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  • Address: Shuangta South Alley 46,2-1, YingZe Area,Taiyuan, ShanXi null,ShanXiChina
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147536-97-8 Bosentan

  • Bosentan, 98,00%
  • China Zeniview Chemistry Technology Co., Ltd. [Manufacturer]
  • Tel: +86-25-86088590
  • Fax: +86-25-85612276
  • Address: No.05,No.01 Hangzhongmen Dajie, Nanjing, China 210016 Nanjing CHINA 210016 NanjingCHINA Nanjing,nullChina
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147536-97-8 Bosentan

  • Bosentan
  • China Suzhou Rovathin Foreign Trade Co.,Ltd [Manufacturer]
  • Tel: 86-512-65816829/ 86-512-61978430
  • Fax: 86-512-65816839
  • Address: Suzhou Rovathin Foreign Trade Co.,Ltd
    (Sales Company of Affiliated Plant in China)
    Room 603, 327 of ShiZi Street,
    Suzhou, Jiangsu, China 215006 null,nullChina
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147536-97-8 Bosentan

  • Bosentan, Min 99%
  • China Finechemie Co., Ltd. [Manufacturer]
  • Tel: +86-23-99186710
  • Fax: +86-23-99186729
  • Address: 28th Floor Mordern Building,New-Tech Zone400020 ChongqingCHINA Chongqing,nullChina
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  • China YiPeng Chemical [Manufacturers]
  • Tel: 571 85376369
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  • Address: Building 4,High-tech Industrial Park,No. 588 Feijiatang Road,Xiacheng District, Hangzhou, China null,ZheJiangChina
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147536-97-8 BOSENTAN, 98+%

  • China China Langchem Inc. null
  • Tel: +86-(21)-58956006
  • Fax: +86-(21)-58956100
  • Address: 514 Room, 1# Building, 88# Cailun Road, Zhangjiang High Tech Park, Shanghai 201203, null,nullChina
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147536-97-8 Bosentan

  • Bosentan, 99%UP
  • China Facus Pharmaceutical Co., Ltd. [Manufacturer]
  • Tel: +86-(0)574-62378411
  • Fax: +86-(0)574-62378410
  • Address: 24Fl,Yuanjing Building,Beilun District, Zhejiang 315800 NingboCHINA Ningbo,nullChina
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References of 4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-pyrimidin-2-
ylpyrimidin-4-yl]benzenesulfonamide
Title: Bosentan
CAS Registry Number: 147536-97-8
CAS Name: 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2¢-bipyrimidin]-4-yl]benzenesulfonamide
Synonyms: p-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamide
Manufacturers' Codes: Ro-47-0203
Molecular Formula: C27H29N5O6S
Molecular Weight: 551.61
Percent Composition: C 58.79%, H 5.30%, N 12.70%, O 17.40%, S 5.81%
Literature References: Mixed endothelin receptor antagonist. Prepn: K. Burri et al., CA 2071193; eidem, US 5292740 (1992, 1994 both to Hoffmann-La Roche). Receptor binding study: M. Clozel et al., J. Pharmacol. Exp. Ther. 270, 228 (1994). LC-MS determn in plasma: B. Lausecker, G. Hopfgartner, J. Chromatogr. A 712, 75 (1995). Clinical pharmacology: G. Sütsch et al., Cardiovasc. Drugs Ther. 10, 717 (1996). Clinical pharmacokinetics: C. Weber et al., Clin. Pharmacol. Ther. 60, 124 (1996). Clinical trial in hypertension: H. Krum et al., N. Engl. J. Med. 338, 784 (1998); in pulmonary arterial hypertension: L. J. Rubin et al., ibid. 346, 896 (2002).
 
Derivative Type: Monohydrate
CAS Registry Number: 157212-55-0
Trademarks: Tracleer (Actelion)
Molecular Formula: C27H29N5O6S.H2O
Molecular Weight: 569.63
Percent Composition: C 56.93%, H 5.49%, N 12.29%, O 19.66%, S 5.63%
Properties: White to yellowish powder. Soly (mg/100 ml): water 1.0; aq soln 0.1 (pH 1.1); 0.1 (pH 4.0); 0.2 (pH 5.0); 43 (pH 7.5).
 
Derivative Type: Sodium salt
CAS Registry Number: 150726-52-6
Molecular Formula: C27H28N5NaO6S
Molecular Weight: 573.60
Percent Composition: C 56.54%, H 4.92%, N 12.21%, Na 4.01%, O 16.74%, S 5.59%
Properties: mp 195-198°.
Melting point: mp 195-198°
 
Therap-Cat: Antihypertensive.
Keywords: Endothelin Receptor Antagonist; Antihypertensive.