Home > Name List By n > N-[4-(7-chloro-5-hydroxy-2,3,4, 5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

CAS No 150683-30-0 , N-[4-(7-chloro-5-hydroxy-2,3,4,
5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

  • Name: N-[4-(7-chloro-5-hydroxy-2,3,4,
    5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
  • Synonyms: benzazepine derivative; 32;N-[4-(7-chloro-5-hydroxy-2,3,4,
    5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide;Samsca; OPC 41061; CHEBI:327437; CHEMBL344159; AC1L50C9; 150683-30-0; OPC-41061;
  • CAS Registry Number:
  • Density: 1.311 g/cm3
  • Refractive index: 1.663
  • Molecular Weight: 448.9413
  • InchiKey: GYHCTFXIZSNGJT-UHFFFAOYSA-N
  • InChI: InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-
    19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,
    24,30H,5,8,13H2,1-2H3,(H,28,31)
  • Molecular Formula: C26H25ClN2O3
  • Molecular Structure:CAS No:150683-30-0 N-[4-(7-chloro-5-hydroxy-2,3,4,<br />5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide

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References of N-[4-(7-chloro-5-hydroxy-2,3,4,
5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide
Title: Tolvaptan
CAS Registry Number: 150683-30-0
CAS Name: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
Synonyms: 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
Manufacturers' Codes: OPC-41061
Molecular Formula: C26H25ClN2O3
Molecular Weight: 448.94
Percent Composition: C 69.56%, H 5.61%, Cl 7.90%, N 6.24%, O 10.69%
Literature References: Nonpeptide arginine vasopressin V2 receptor antagonist. Prepn: H. Ogawa et al., WO 9105549; eidem, US 5258510 (1991, 1993 both to Otsuka); K. Kondo et al., Bioorg. Med. Chem. 7, 1743 (1999). Pharmacology: Y. Yamamura et al., J. Pharmacol. Exp. Ther. 287, 860 (1998). Clinical trial in heart failure: M. Gheorghiade et al., J. Am. Med. Assoc. 291, 1963 (2004).
Properties: Colorless prisms, mp 225.9°.
Melting point: mp 225.9°
Therap-Cat: In treatment of congestive heart failure.
Keywords: Vasopressin Receptor Antagonist.