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CAS No 152-47-6 , 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

  • Name: 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
  • Synonyms: Kelfizine; Kelfizin; Longum; Dalysep; Polycidal;4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide; Kelfizina;Sulfamethopyrazine; Sulfametopyrazine; Sulfalen;
  • CAS Registry Number:
  • Melting Point: 174~178ºC
  • Density: 1.465 g/cm3
  • Refractive index: 1.646
  • Water Solubility: Hardly soluble in water,slightly soluble in ethanol, ethyl ether and propyl ether
  • Safety Statements: Moderately toxic by ingestion, subcutaneous, and intravenous routes. An experimental teratogen. Experimental reproductive effects. Mutation data reported. An antibacterial agent. When heated to decomposition it emits very toxic fumes of NOx and SOx. See also SULFONATES.
  • EINECS: 205-804-7
  • Molecular Weight: 280.30298
  • InchiKey: KXRZBTAEDBELFD-UHFFFAOYSA-N
  • InChI: InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,
    17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)
  • Molecular Formula: C11H12N4O3S
  • Molecular Structure:CAS No:152-47-6 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide

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References of 4-amino-N-(3-methoxypyrazin-2-yl)benzenesulfonamide
Title: Sulfalene
CAS Registry Number: 152-47-6
CAS Name: 4-Amino-N-(3-methoxypyrazinyl)benzenesulfonamide
Synonyms: N1-(3-methoxy-2-pyrazinyl)sulfanilamide; 2-(p-aminobenzenesulfonamido)-3-methoxypyrazine; 3-methoxy-2-sulfanilamidopyrazine; sulfamethopyrazine; 2-sulfanilamido-3-methoxypyrazine; sulfamethoxypyrazine; sulfapyrazinemethoxyine
Manufacturers' Codes: Farmitalia 204/122
Trademarks: Dalysep (Syntex); Kelfizina (Farmitalia); Kelfizine W (Farmitalia); Longum (Farmitalia); Policydal (Eisai); Vetkelfizina (Centralvet)
Molecular Formula: C11H12N4O3S
Molecular Weight: 280.30
Percent Composition: C 47.13%, H 4.32%, N 19.99%, O 17.12%, S 11.44%
Literature References: Prepn: B. Camerino, G. Palamidessi, Gazz. Chim. Ital. 90, 1815 (1960); GB 928151; US 3098069 (both 1963 to Farmitalia). Review: Gasparini, Veterinaria (Milan) 20, 302 (1971). Also used in combination with trimethoprim, q.v. Toxicology: V. De Pascale et al., Boll. Chim. Farm. 116, 155 (1977). Pharmacodynamics: D. S. Reeves et al., J. Antimicrob. Chemother. 6, 647 (1980). Clinical assessment: H. Harazim et al., J. Int. Med. Res. 11, 197 (1983); M. L. Colombo et al., Pharmatherapeutica 3, 556 (1984). Review of clinical efficacy: F. Celotti et al., J. Int. Med. Res. 14, 236-241 (1986).
Properties: Crystals from alcohol, mp 176°. LD50 in mice (g/kg): 2.164 orally; 1.41 i.v. (US 3098069).
Melting point: mp 176°
Toxicity data: LD50 in mice (g/kg): 2.164 orally; 1.41 i.v. (US 3098069)
 
Derivative Type: Mixture with trimethoprim
CAS Registry Number: 50933-06-7
Trademarks: Kelfiprim (Farmitalia)
Properties: LD50 in mice, rats (mg/kg): 3500; 3550 orally (De Pascale).
Toxicity data: LD50 in mice, rats (mg/kg): 3500; 3550 orally (De Pascale)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Synthetic); Sulfonamides.