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CAS No 1524-88-5 , Flurandrenolide Search by region : Germany

  • Name: Flurandrenolide
  • Synonyms: Fluorandrenolone; Fludroxicortidum; Haelan;flurandrenolide; Sermaka; Drocort; Drenison; Fludroxycortide;Flurandrenolide; Cordran;
  • CAS Registry Number:
  • Melting Point: 209 - 219
  • Flash Point: 303.8°C
  • Boiling Point: 578.7°Cat760mmHg
  • Density: 1.31g/cm3
  • Refractive index: 1.572
  • Flash Point: 303.8°C
  • EINECS: 216-196-8
  • Molecular Weight: 436.513623
  • InchiKey: POPFMWWJOGLOIF-XWCQMRHXSA-N
  • InChI: InChI=1S/C24H33FO6/c1-21(2)30-19-9-14-13-8-16(25)15-7-12(27)5-6-22(15,
    3)20(13)17(28)10-23(14,4)24(19,31-21)18(29)11-26/h7,13-14,16-17,19-20,
    26,28H,5-6,8-11H2,1-4H3/t13-,14-,16-,17-,19+,20+,22-,23-,24+/m0/s1
  • Molecular Formula: C24H33FO6
  • Molecular Structure:CAS No:1524-88-5 Flurandrenolide

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1524-88-5 Flurandrenolide

  • Flurandrenolide
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
  • Fax: 0049 9402/9336 13
  • Address: CHEMOS GmbH
    Werner-von-Siemensstr. 3
    93128 Regenstauf
    Germany null,nullGermany
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References of Flurandrenolide
Title: Flurandrenolide
CAS Registry Number: 1524-88-5
CAS Name: (6a,11b,16a)-6-Fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregn-4-ene-3,20-dione
Synonyms: 6a-fluoro-11b,16a,17,21-tetrahydroxypregn-4-ene-3,20-dione cyclic 16,17-acetal with acetone; 6a-fluoro-16a,17a-isopropylidenedioxy-4-pregnene-11b,21-diol-3,20-dione; 6a-fluoro-11b,16a,17,21-tetrahydroxyprogesterone cyclic 16,17-acetal with acetone; fludroxycortide; fluorandrenolone; flurandrenolone; flurandrenolone acetonide
Trademarks: Cordran (Watson); Drenison (Lilly); Drocort (Lilly); Sermaka (Lilly)
Molecular Formula: C24H33FO6
Molecular Weight: 436.51
Percent Composition: C 66.04%, H 7.62%, F 4.35%, O 21.99%
Literature References: Prepn: H. J. Ringold et al., DE 1131213; eidem, US 3126375 (1962, 1964 both to Syntex). HPLC determn in pharmaceutical cream: R. Pearlman et al., Int. J. Pharm. 18, 53 (1984); in urine: E. Neufeld et al., J. Chromatogr. B 718, 273 (1998). Clinical trial in psoriasis: G. G. Krueger et al., J. Am. Acad. Dermatol. 38, 186 (1998).
Properties: Crystals from acetone + hexane, mp 247-255°. [a]D +140-150° (CHCl3). uv max: 236 nm (log e 4.17).
Melting point: mp 247-255°
Optical Rotation: [a]D +140-150° (CHCl3)
Absorption maximum: uv max: 236 nm (log e 4.17)
Therap-Cat: Glucocorticoid; antipsoriatic.
Keywords: Glucocorticoid; Antipsoriatic.