Home > Name List By 2 > 2,2-dichloro-N-[(1R,2R)-1, 3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide

CAS No 15318-45-3 , 2,2-dichloro-N-[(1R,2R)-1,
3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide

  • Name: 2,2-dichloro-N-[(1R,2R)-1,
    3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
  • Synonyms: (+)-Thiamphenicol; Macphenicol;Thiophenicol;2,2-dichloro-N-[(1R,2R)-1,
    3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide; 15318-45-3; Thiamphenicolum; Thiamcol; Thiocymetin; Dextrosulphenidol;
  • CAS Registry Number:
  • Melting Point: 163-166 °C
  • Flash Point: 374.7°C
  • Boiling Point: 695.9°Cat760mmHg
  • Density: 1.491g/cm3
  • Refractive index: 1.589
  • Safety Statements: Poison by intravenous route. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. Human systemic effects by an unspecified route: sleep disorders, dermatitis, nausea or vomiting. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of SOx, NOx, and Cl−. See also CHLORAMPHENICOL.
  • Flash Point: 374.7°C
  • EINECS: 239-355-3
  • Molecular Weight: 356.2222
  • InchiKey: OTVAEFIXJLOWRX-NXEZZACHSA-N
  • InChI: InChI=1S/C12H15Cl2NO5S/c1-21(19,
    20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,
    1H3,(H,15,18)/t9-,10-/m1/s1
  • Molecular Formula: C12H15Cl2NO5S
  • Molecular Structure:CAS No:15318-45-3 2,2-dichloro-N-[(1R,2R)-1,<br />3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide

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References of 2,2-dichloro-N-[(1R,2R)-1,
3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Title: Thiamphenicol
CAS Registry Number: 15318-45-3
CAS Name: 2,2-Dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
Synonyms: D-d-threo-2-dichloroacetamido-1-(4-methylsulfonyl)phenyl-1,3-propanediol; dextrosulphenidol
Manufacturers' Codes: Win-5063-2; 8053CB
Trademarks: Hyrazin (Kowa); Igralin (Zeria); Neomyson (Eisai); Rigelon (Dojin); Thiamcol (Morishita); Thionicol (Mohan); Thiophenicol (Clin Comar); Urfamycine (Inpharzam); Urophenil (Nippon Seiyaku)
Molecular Formula: C12H15Cl2NO5S
Molecular Weight: 356.22
Percent Composition: C 40.46%, H 4.24%, Cl 19.91%, N 3.93%, O 22.46%, S 9.00%
Literature References: Synthesis: Cutler et al., J. Am. Chem. Soc. 74, 5475 (1952); Suter et al., ibid. 75, 4330 (1953); Suter, US 2759927; US 2759970; US 2759971; US 2759972; US 2759976 (all 1956 to Sterling Drugs); GB 770277 (1957 to Parke, Davis).
Properties: Crystals, mp 164.3-166.3°. [a]D25 +12.9° (ethanol). uv max (95% ethanol): 224, 266, 274 nm (e 13,700, 800, 700). Appreciably sol in water. Soluble in alcohol.
Melting point: mp 164.3-166.3°
Optical Rotation: [a]D25 +12.9° (ethanol)
Absorption maximum: uv max (95% ethanol): 224, 266, 274 nm (e 13,700, 800, 700)
 
Derivative Type: DL-Form
CAS Registry Number: 847-25-6
Synonyms: Raceophenidol; racephenicol
Trademarks: Dexawin (Winthrop); Thiocymetin (Winthrop)
 
Therap-Cat: Antibacterial.
Therap-Cat-Vet: D-Form as antimicrobial; DL-form in control of fowl cholera.
Keywords: Antibacterial (Antibiotics); Amphenicols.