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CAS No 1538-09-6 , Benzathine benzylpenicillin Search by region : Germany

  • Name: Benzathine benzylpenicillin
  • Synonyms: Benzathine benzylpenicillin; (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid with N,N'-Dibenzylethylenediamine (2:1);N,N'-Dibenzylethylethylenediamine Bis(benzylpenicillin);
  • CAS Registry Number:
  • Flash Point: 355 ºC
  • Boiling Point: 663.3 ºCat 760 mmHg
  • Safety Statements: Moderately toxic by ingestion and intraperitoneal routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx and SOx. See other penicillin entries.
  • Hazard Symbols: Xn: Harmful;
  • Flash Point: 355 ºC
  • EINECS: 216-260-5
  • Molecular Weight: 909.13
  • InChI: InChI=1/2C16H18N2O4S.C16H20N2/c2*1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;1-3-7-15(8-4-1)13-17-11-12-18-14-16-9-5-2-6-10-16/h2*3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);1-10,17-18H,11-14H2/t2*11-,12+,14-;/m11./s1
  • Risk Statements: 22-42/43
  • Molecular Formula: C16H20N2.2(C16H18N2O4S)
  • Molecular Structure:CAS No:1538-09-6 Benzathine benzylpenicillin

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1538-09-6 Benzathine penicillin G

  • Benzathine penicillin G
  • Germany CHEMOS GmbH [Manufacturer]
  • Tel: 0049 9402/9336 0
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  • Address: CHEMOS GmbH
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    Germany null,nullGermany
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References of Benzathine benzylpenicillin
Title: Penicillin G Benzathine
CAS Registry Number: 1538-09-6
CAS Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid compd with N,N￠-bis(phenylmethyl)-1,2-ethanediamine (2:1)
Synonyms: penicillin G N,N￠-dibenzylethylenediamine salt; N,N￠-dibenzylethylenediamine bis[benzylpenicillin]; dibenzylethylenediamine dipenicillin G; benzethacil; benzathine penicillin G; DBED-penicillin
Trademarks: Beacillin (EGYT); Bicillin L-A (Wyeth-Ayerst); Cepacilina (CEPA); Extencilline (RPR); Lentopenil (Grossman); Megacillin (susp.) (Frosst); Penidural (Am. Home); Permapen (Roerig); Tardocillin (Bayer)
Molecular Formula: C48H56N6O8S2
Molecular Weight: 909.12
Percent Composition: C 63.41%, H 6.21%, N 9.24%, O 14.08%, S 7.05%
Literature References: Repository form of penicillin. Prepn: J. L. Szabo et al., Antibiot. Chemother. 1, 499 (1951); J. L. Szabo, W. F. Bruce, US 2627491 (1953 to Wyeth). Comprehensive description: F. Kreuzig, Anal. Profiles Drug Subs. 11, 463-482 (1982). Review of clinical efficacy in syphilis: E. W. Hook, III, Rev. Infect. Dis. 11, Suppl. 6, S1511-S1517 (1989); in prophylaxis of rheumatic fever: B. J. Currie, Pediatrics 97, 989 (1996).
Properties: Crystals from formamide, mp 123-124°. [a]D25 +206° (c = 0.105 in formamide). Soly at 23° (mg/ml): water 0.15; benzene 0.38; alc 5.2; acetone 1.5; formamide 28.0. pH of satd aq soln about 6. Solubilities determined by Weiss et al., Antibiot. Chemother. 7, 374 (1957) in mg/ml: water 0.315; methanol 16.9; ethanol 15.4.
Melting point: mp 123-124°
Optical Rotation: [a]D25 +206° (c = 0.105 in formamide)
Therap-Cat: Antibacterial.
Therap-Cat-Vet: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Penicillins.