Home > Name List By other > (4R,5S,6S)-3-[(3S, 5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1- hydroxyethyl]-4-methyl-7-oxo-1-azabi...

CAS No 153832-46-3 , (4R,5S,6S)-3-[(3S,
5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
acid

  • Name: (4R,5S,6S)-3-[(3S,
    5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
    hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
    acid
  • Synonyms: Ertapenem (INN); Ertapenem [INN]; Invanz (TN); UNII-G32F6EID2H; CHEBI:404903;(4R,5S,6S)-3-[(3S,
    5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
    hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
    acid; CHEMBL1359; AC1L44OL; 153832-46-3;Invanz;
  • CAS Registry Number:
  • Density: 1.55 g/cm3
  • Refractive index: 1.7
  • Molecular Weight: 475.5148
  • InchiKey: JUZNIMUFDBIJCM-ANEDZVCMSA-N
  • InChI: InChI=1S/C22H25N3O7S/c1-9-16-15(10(2)26)20(28)25(16)17(22(31)32)18(9)33-
    13-7-14(23-8-13)19(27)24-12-5-3-4-11(6-12)21(29)30/h3-6,9-10,13-16,23,
    26H,7-8H2,1-2H3,(H,24,27)(H,29,30)(H,31,32)/t9-,10-,13+,14+,15-,
    16-/m1/s1
  • Molecular Formula: C22H25N3O7S
  • Molecular Structure:CAS No:153832-46-3 (4R,5S,6S)-3-[(3S,<br />5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-<br />hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic<br />acid

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References of (4R,5S,6S)-3-[(3S,
5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-6-[(1R)-1-
hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic
acid
Title: Ertapenem
CAS Registry Number: 153832-46-3
CAS Name: [4R,5S,6S]-3-[[(3S,5S)-5-[[(3-Carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Synonyms: (1R,5S,6S,8R,2￠S,4￠S)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid
Manufacturers' Codes: ZD-443
Molecular Formula: C22H25N3O7S
Molecular Weight: 475.51
Percent Composition: C 55.57%, H 5.30%, N 8.84%, O 23.55%, S 6.74%
Literature References: Group 1 carbapenem antibiotic. Prepn: M. J. Betts et al., WO 9315078; eidem, US 5478820 (1993, 1995 both to Zeneca). Large-scale synthesis: J. M. Williams et al., J. Org. Chem. 70, 7479 (2005). Pharmacokinetics in primates: J. G. Sundelof et al., Antimicrob. Agents Chemother. 41, 1743 (1997). In vivo efficacy and pharmacokinetics: C. J. Gill et al., ibid. 42, 1996 (1998). In vitro efficacy and b-lactamase stability: J. Kohler et al., ibid. 43, 1170 (1999). HPLC determn in plasma and urine: D. G. Musson et al., J. Chromatogr. B 720, 99 (1998); of residual crystallization solvents: T. K. Natishan, Y. Wu, ibid. A 800, 275 (1998). Series of articles on pharmacology and clinical experience in complicated community-acquired infections: J. Antimicrob. Chemother. 53, Suppl. S2, ii1-ii86 (2004).
 
Derivative Type: Sodium salt
CAS Registry Number: 153832-38-3
Manufacturers' Codes: MK-826
Trademarks: Invanz (Merck & Co.)
Molecular Formula: C22H24N3NaO7S
Molecular Weight: 497.50
Percent Composition: C 53.11%, H 4.86%, N 8.45%, Na 4.62%, O 22.51%, S 6.45%
Properties: White to off-white hygroscopic, weakly crystalline powder. Sol in water, 0.9% sodium chloride soln. Practically insol in ethanol; insol in isopropyl acetate, THF.
 
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); ?Lactams; Carbapenems.