Home > Name List By 1 > 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2, 2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2, 3-dihydroindole-7-carboxamide

CAS No 160970-54-7 , 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,
2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,
3-dihydroindole-7-carboxamide

  • Name: 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,
    2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,
    3-dihydroindole-7-carboxamide
  • Synonyms: Silodosin; KAD 3213;1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,
    2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,
    3-dihydroindole-7-carboxamide; 160970-54-7; Urief; KMD-3213; Rapaflo;
  • CAS Registry Number:
  • Density: 1.249 g/cm3
  • Molecular Weight: 495.53449
  • InchiKey: PNCPYILNMDWPEY-QGZVFWFLSA-N
  • InChI: InChI=1S/C25H32F3N3O4/c1-17(30-8-12-34-21-5-2-3-6-22(21)35-16-25(26,
    27)28)13-18-14-19-7-10-31(9-4-11-32)23(19)20(15-18)24(29)33/h2-3,5-6,
    14-15,17,30,32H,4,7-13,16H2,1H3,(H2,29,33)/t17-/m1/s1
  • Molecular Formula: C25H32F3N3O4
  • Molecular Structure:CAS No:160970-54-7 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,<br />2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,<br />3-dihydroindole-7-carboxamide

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160970-54-7 1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-

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160970-54-7 1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-

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160970-54-7 1H-Indole-7-carboxamide,2,3-dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-

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References of 1-(3-hydroxypropyl)-5-[(2R)-2-[2-[2-(2,2,
2-trifluoroethoxy)phenoxy]ethylamino]propyl]-2,
3-dihydroindole-7-carboxamide
Title: Silodosin
CAS Registry Number: 160970-54-7
CAS Name: 2,3-Dihydro-1-(3-hydroxypropyl)-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carboxamide
Manufacturers' Codes: KMD-3213
Molecular Formula: C25H32F3N3O4
Molecular Weight: 495.53
Percent Composition: C 60.60%, H 6.51%, F 11.50%, N 8.48%, O 12.91%
Literature References: a1a-Adrenoceptor antagonist. Prepn: M. Kitazawa et al., EP 600675; eidem, US 5387603 (1994, 1995 both to Kissei). Adrenoceptor binding study: K. Shibata et al., Mol. Pharmacol. 48, 250 (1995); and tissue selectivity: S. Murata et al., J. Urol. 164, 578 (2000). Pharmacology: K. Akiyama et al., Pharmacology 64, 140 (2002). Series of articles on pharmacology, pharmacokinetcs and toxicology: Yakugaku Zasshi 126, 187-263 (2006). Review of development and therapeutic potential: F. Kamali, Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs 1, 248-252 (1999).
Properties: [a]D25 -14.0° (c = 1.01 in methanol).
Optical Rotation: [a]D25 -14.0° (c = 1.01 in methanol)
Therap-Cat: In treatment of benign prostatic hypertophy.
Keywords: a-Adrenergic Blocker.